5,7-Dichlorokynurenic acid

(HB0078)
Technical documents: SDS Datasheet

Product overview

Name 5,7-Dichlorokynurenic acid
Alternative names DCKA; 5,7-DCK
Purity >98%
Description Potent, selective, competitive glycine site NMDA receptor antagonist
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5,7-Dichlorokynurenic acid: Scientist Approved

Biological Data

Biological description Potent, selective and competitive NMDA receptor antagonist (Ki = 79 nM). Binds at the glycine site. Neuroprotective actions in cell culture.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in 0.1M NaOH (100mM) and in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

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Chemical Data

Purity >98%
Chemical name 5,7-Dichloro-4-hydroxyquinoline-2-carboxylic acid
Molecular Weight 258.06
Chemical structure 5,7-Dichlorokynurenic acid  [131123-76-7] Chemical Structure
Molecular Formula C10H5Cl2NO3
CAS Number 131123-76-7
PubChem identifier 1779
SMILES C1=C(C=C2C(=C1Cl)C(=O)C=C(N2)C(=O)O)Cl
InChi InChI=1S/C10H5Cl2NO3/c11-4-1-5(12)9-6(2-4)13-7(10(15)16)3-8(9)14/h1-3H,(H,13,14)(H,15,16)
InChiKey BGKFPRIGXAVYNX-UHFFFAOYSA-N
MDL number MFCD00083173

References for 5,7-Dichlorokynurenic acid

References are publications that support the biological activity of the product
  • Activity of 5,7-dichlorokynurenic acid, a potent antagonist at the N-methyl-D-aspartate receptor-associated glycine binding site.

    Baron BM et al (1990) Mol Pharmacol 38(4) : 554-61.
  • 5,7-Dichlorokynurenic acid, a potent and selective competitive antagonist of the glycine site on NMDA receptors.

    McNamara D et al (1990) Neurosci Lett 120(1) : 17-20.

2 Item(s)

Publications
These publications cite the use of 5,7-Dichlorokynurenic acid purchased from Hello Bio:
  • Structural Basis for Negative Allosteric Modulation of GluN2A-Containing NMDA Receptors.

    Yi et al (2016) Neuron 91(6) : 1316-29
    PubMedID: 27618671

1 Item