(+)-Bicuculline

(HB0896)

Product overview

  • Name
    (+)-Bicuculline
  • Short description
    Competitive GABAA receptor antagonist
  • Biological description
    Competitive GABAA receptor antagonist. Also acts on calcium-dependent potassium channels.
  • Biological action
    Antagonist
  • Purity
    >99%
  • Our products in action

Properties

  • Chemical name
    [R-(R*,S*)]-6-(5,6,7,8-Tetrahydro-6 -methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)furo[3, 4-e]-1,3-benzodioxol-8(6H)-one
  • Molecular Weight
    367.36
  • Chemical structure
    (+)-Bicuculline  [485-49-4]
  • Molecular Formula
    C20H17NO6
  • CAS Number
    485-49-4
  • PubChem identifier
    10237
  • SMILES
    CN1CCC2=CC3=C(C=C2[C@H]1[C@H]4C5=C(C6=C(C=C5)OCO6)C(=O)O4)OCO3
  • InChi
    InChI=1S/C20H17NO6/c1-21-5-4-10-6-14-15(25-8-24-14)7-12(10)17(21)18-11-2-3-13-19(26-9-23-13)16(11)20(22)27-18/h2-3,6-7,17-18H,4-5,8-9H2,1H3/t17-,18+/m0/s1
  • InChiKey
    IYGYMKDQCDOMRE-ZWKOTPCHSA-N
  • MDL number
    MFCD00005006

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    Soluble in ethanol (5mM, gentle warming) and in DMSO (100mM)

References for (+)-Bicuculline

  • Advantages of an antagonist: bicuculline and other GABA antagonists.

    Johnston GA (2013) Br J Pharmacol 169(2) : 328-36.
    PubMedID: 23425285
  • Differential effects of iontophoretic in vivo application of the GABA(A)-antagonists bicuculline and gabazine in sensory cortex.

    Kurt S et al (2006) Hear Res 212(1-2) : 224-35.
    PubMedID: 16442250
  • [Bicuculline inhibits airway remodeling in a murine model of chronic asthma].

    Zhu T et al (2010) Nan Fang Yi Ke Da Xue Xue Bao 30(4) : 842-6.
    PubMedID: 20423862

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