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Biological Data
| Biological description | Potent KCa1.1 channel activator. Displays vasodilation and neuroprotective properties. Blood brain barrier permeable. |
Solubility & Handling
| Storage instructions | Room temperature |
| Solubility overview | Soluble in DMSO (100mM) or ethanol (15mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use |
Chemical Data
| Chemical name | 3-[(5-Chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2( 3H)-one |
| Chemical structure | ![BMS 191011 [202821-81-6] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "BMS 191011 [202821-81-6]") |
| Molecular Formula | C16H10ClF3N2O3 |
| PubChem identifier | 10474339 |
| SMILES | OC1=CC=C(Cl)C=C1CN1N=C(OC1=O)C1=CC=C(C=C1)C(F)(F)F |
| InChi | InChI=1S/C16H10ClF3N2O3/c17-12-5-6-13(23)10(7-12)8-22-15(24)25-14(21-22)9-1-3-11(4-2-9)16(18,19)20/h1-7,23H,8H2 |
| InChiKey | QKOWACXSXTXRKA-UHFFFAOYSA-N |
References for BMS 191011
References are publications that support the biological activity of the product
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BMS-191011, an opener of large-conductance Ca2+-activated potassium channels, dilates rat retinal arterioles in vivo.
Mori A et al (2011) Biol Pharm Bull 34(1) : 150-2. -
3-[(5-Chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl ]-1,3,4-oxadiazol-2(3H)-one, BMS-191011: opener of large-conductance Ca(2+)-activated potassium (maxi-K) channels, identification, solubility, and SAR.
Romine JL et al (2007) J Med Chem 50(3) : 528-42. -
Synthesis of water-soluble prodrugs of BMS-191011: a maxi-K channel opener targeted for post-stroke neuroprotection.
Hewawasam P et al (2003) Bioorg Med Chem Lett 13(10) : 1695-8.
Potent KCa1.1 channel activator
![BMS 191011 [202821-81-6] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1043.png "BMS 191011 [202821-81-6]")
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