Dexamethasone

(HB2521)

Product overview

  • Name
    Dexamethasone
  • Short description
    Synthetic glucocorticoid. Differentiates MSCs into adipogenic, chondrogenic and osteogenic lineages.
  • Biological description
    Synthetic glucocorticoid (IC50 = 10 nM). Differentiates mesenchymal stem cells (MSCs) into adipogenic, chondrogenic and osteogenic lineages. Also shows potent anti-inflammatory and immunospressant effects. Active in vivo.
  • Alternative names
    Dex
  • Biological action
    Agonist
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    (11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methyl-pregna-1,4-diene-3,20-dione
  • Molecular Weight
    392.47
  • Chemical structure
    Dexamethasone [50-02-2]
  • Molecular Formula
    C22H29FO5
  • CAS Number
    50-02-2
  • PubChem identifier
    5743
  • SMILES
    C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)F)C
  • InChi
    InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
  • InChiKey
    UREBDLICKHMUKA-CXSFZGCWSA-N
  • MDL number
    MFCD00064136

Storing and Using Your Product

  • Storage instructions
    -20°C. Protect from light.
  • Solubility overview
    Soluble in DSMO (100mM)

References for Dexamethasone

  • Dexamethasone alleviates tumor-associated brain damage and angiogenesis.

    Fan Z et al (2014) PLoS One 9(4) : e93264.
    PubMedID: 24714627
  • Glucocorticoid receptor antagonism by cyproterone acetate and RU486.

    Honer C et al (2003) Mol Pharmacol 63(5) : 1012-20.
    PubMedID: 12695529
  • Short bouts of mechanical loading are as effective as dexamethasone at inducing matrix production by human bone marrow mesenchymal stem cell.

    Sittichokechaiwut A et al (2010) Eur Cell Mater 20 : 45-57.
    PubMedID: 20648425