The store will not work correctly in the case when cookies are disabled.
Biological Data
| Biological description | Selective H2 receptor agonist. Also inhibits nNOS (IC50 = 49 µM for rat nNOS). Shows cytoprotective and hypotensive actions. |
Solubility & Handling
| Storage instructions | Room temperature (desiccate) |
| Solubility overview | Soluble in water (100 mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use |
Chemical Data
| Chemical name | S-(3-Dimethylaminopropyl)isothioure a dihydrochloride |
| Chemical structure | ![Dimaprit dihydrochloride [23256-33-9] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "Dimaprit dihydrochloride [23256-33-9]") |
| Molecular Formula | C6H15N3S.2HCl |
| SMILES | CN(C)CCCSC(=N)N.Cl.Cl |
| InChi | InChI=1S/C6H15N3S.2ClH/c1-9(2)4-3-5-10-6(7)8;;/h3-5H2,1-2H3,(H3,7,8);2*1H |
| InChiKey | DFWCPLGXFMSUCW-UHFFFAOYSA-N |
References for Dimaprit dihydrochloride
References are publications that support the biological activity of the product
-
Suppression of ischaemia-induced cytokine release by dimaprit and amelioration of liver injury in rats.
Motoki A et al (2008) Basic Clin Pharmacol Toxicol 102(4) : 394-8. -
Nitric oxide synthase inhibition by dimaprit and dimaprit analogues.
Paquay JB et al (1999) Br J Pharmacol 127(2) : 331-4. -
Cardiovascular effects of the novel histamine H2 receptor agonist amthamine: interaction with the adrenergic system.
Coruzzi G et al (1996) Naunyn Schmiedebergs Arch Pharmacol 353(4) : 417-22. -
Dimaprit -(S-[3-(N,N-dimethylamino)prophyl]isothiourea) - a highly specific histamine H2 -receptor agonist. Part 1. Pharmacology.
Parsons ME et al (1977) Agents Actions 7(1) : 31-7.
Selective H2 receptor agonist
![Dimaprit dihydrochloride [23256-33-9] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb2626.png "Dimaprit dihydrochloride [23256-33-9]")
Understanding purity and quality - a guide for life scientists