Product overview

  • Name
    Etomidate
  • Short description
    Potent GABAA receptor positive allosteric modulator
  • Biological description
    Potent GABAA receptor positive allosteric modulator. Selective for β2 and β3 subunits (EC50 values are 0.6, 0.7 and 7.4 µM for α6β2γ2, α6β3γ2 and α6β1γ2 GABAA receptor subtypes respectively). Shows short acting hypnotic actions. Blood-brain barrier permeable.
  • Biological action
    PAM
  • Purity
    >99%
  • Our products in action

Properties

  • Chemical name
    (R)-1-(1-Phenylethyl)-1H-imidazole-5-carboxylic acid ethyl ester
  • Molecular Weight
    244.29
  • Chemical structure
    Etomidate  [33125-97-2]
  • Molecular Formula
    C14H16N2O2
  • CAS Number
    33125-97-2
  • PubChem identifier
    36339
  • SMILES
    CCOC(=O)C1=CN=CN1C(C)C2=CC=CC=C2
  • InChi
    InChI=1S/C14H16N2O2/c1-3-18-14(17)13-9-15-10-16(13)11(2)12-7-5-4-6-8-12/h4-11H,3H2,1-2H3
  • InChiKey
    NPUKDXXFDDZOKR-UHFFFAOYSA-N
  • MDL number
    MFCD00869295

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Solubility overview
    Soluble in ethanol (100mM) and in 1M HCl (50mM)

References for Etomidate

  • Distinct actions of etomidate and propofol at beta3-containing gamma-aminobutyric acid type A receptors.

    Drexler B et al (2009) Neuropharmacology 57(4) : 446-55.
    PubMedID: 19555700
  • Etomidate and other non-barbiturates.

    Vanlersberghe C et al (2008) Handb Exp Pharmacol -182 : 267-82.
    PubMedID: 18175096
  • The interaction of the general anesthetic etomidate with the gamma-aminobutyric acid type A receptor is influenced by a single amino acid.

    Belelli D et al (1997) Proc Natl Acad Sci U S A 94(20) : 11031-6.
    PubMedID: 9380754

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