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HC 067047

(HB1191)
Publications (2)
Technical documents: SDS CoA Datasheet

Product overview

Name HC 067047
Purity >98%
Description Potent, selective TRPV4 channel antagonist
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews Publications (2) References (3) Frequently bought together
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HC 067047 product vial image | Hello Bio
HC 067047 product vial image | Hello Bio

HC 067047 product vial image | Hello Bio

HC 067047 product vial image | Hello Bio

Biological Data

Biological description Potent and selective TRPV4 channel antagonist (IC50 values are 17, 48 and 133 nM for mouse, human and rat TRPV4 channels respectively). Increases ATP release from porcine lenses (IC50 = 2.5 µM). Also reduces 4α-phorbol 12,13-didecanoate (4α-PDD)-induced Ca2+ responses (IC50 = 22 nM). Exhibits reduced activity for TRPM8 and hERG channels.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (100mM) and in ethanol (25mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name 2-Methyl-1-[3-(4-morpholinyl)propyl ]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide
Molecular Weight 471.5
Chemical structure HC 067047 [883031-03-6] Chemical Structure
Molecular Formula C26H28F3N3O2
CAS Number 883031-03-6
PubChem identifier 2742550
SMILES CC1=C(C=C(N1CCCN2CCOCC2)C3=CC=CC=C3)C(=O)NC4=CC=CC(=C4)C(F)(F)F
Source Synthetic
InChi InChI=1S/C26H28F3N3O2/c1-19-23(25(33)30-22-10-5-9-21(17-22)26(27,28)29)18-24(20-7-3-2-4-8-20)32(19)12-6-11-31-13-15-34-16-14-31/h2-5,7-10,17-18H,6,11-16H2,1H3,(H,30,33)
InChiKey NCZYSQOTAYFTNM-UHFFFAOYSA-N
MDL number MFCD01571257
Appearance White solid

References for HC 067047

References are publications that support the biological activity of the product

  • TRPV4 in porcine lens epithelium regulates hemichannel-mediated ATP release and Na-K-ATPase activity.

    Shahidullah M et al (2012) Am J Physiol Cell Physiol 302(12) : C1751-61.
    Read more (PubMedID: 22492652)

  • Implication of the ryanodine receptor in TRPV4-induced calcium response in pulmonary arterial smooth muscle cells from normoxic and chronically hypoxic rats.

    Dahan D et al (2012) Am J Physiol Lung Cell Mol Physiol 303(9) : L824-33.
    Read more (PubMedID: 22962011)

  • Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis.

    Everaerts W et al (2010) Proc Natl Acad Sci U S A 107(44) : 19084-9.
    Read more (PubMedID: 20956320)

3 Item(s)

Publications
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These publications cite the use of HC 067047 purchased from Hello Bio:

  • TRPV4 and TRPC1 channels mediate the response to tensile strain in mouse Müller cells.

    Jo AO et al (2022) Cell calcium 104 : 102588
    PubMedID: 35398674

  • TRPV4 Antagonism Prevents Mechanically Induced Myotonia

    Dupont C et al (2020) Ann Neurol 88(2) : 297-308
    PubMedID: 32418267

2 Item(s)

Grouped product items
Order: HB1191
Pack PriceQty
5mg
$74
25mg
$279
Potent, selective TRPV4 channel antagonist
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

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