Product overview

Name Metformin hydrochloride
Description LKB1/AMPK activator. Also promotes neurogenesis.
Write Your Own Review
You're reviewing:Metformin hydrochloride
Rate this item:

Biological Data

Biological description

LKB1/AMPK activator which is blood brain barrier permeable.

It improves insulin sensitivity and decreases plasma glucose levels to show antidiabetic activity.

Additionally, it displays antiproliferative effects in cancer cell lines, inhibits cancer stem cells (CSCs) and shows anticancer and anti-neoplastic effects. It also promotes neurogenesis by activating the PKC-CBP pathway.

Recently investigated as part of COVID-19 compound repurposing.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in water (100mM) or DMSO (50mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

=
x
x
More Info

Dilution

x
=
x
More Info

Chemical Data

Chemical name N,N-Dimethylimidodicarbonimidic diamide hydrochloride
Molecular Weight 165.62
Chemical structure Metformin hydrochloride |  [1115-70-4] Chemical Structure
Molecular Formula C4H11N5.HCl
CAS Number 1115-70-4
PubChem identifier 14219
SMILES CN(C)C(=N)N=C(N)N.Cl
InChi InChI=1S/C4H11N5.ClH/c1-9(2)4(7)8-3(5)6;/h1-2H3,(H5,5,6,7,8);1H
InChiKey OETHQSJEHLVLGH-UHFFFAOYSA-N
MDL number MFCD00012582
Appearance White solid

References for Metformin hydrochloride

References are publications that support the biological activity of the product
  • A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

    Krogan et al (2020) Nature 7816 : 459-468
  • Metformin, cancer and glucose metabolism.

    Salani et al (2014) Endocr Relat Cancer 21(6) : 461-71
  • Metformin activates an atypical PKC-CBP pathway to promote neurogenesis and enhance spatial memory formation.

    Wang et al (2012) Cell Stem Cell 11(1) : 23-35
  • AMP-activated protein kinase in metabolic control and insulin signaling.

    Towler and Hardie (2007) Circ Res 100(3) : 32841

4 Item(s)