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Biological Data
| Biological description | Potent, selective P2Y6 receptor antagonist (IC50 = 98 nM). Reduces monocyte IL-8 release. Shows antinociceptive actions. |
Solubility & Handling
| Storage instructions | -20°C (desiccate) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | N,N''-1,4-Butanediylbis[N'-(3-isothioc yanatophenyl)thiourea |
| Molecular Formula | C20H20N6S4 |
| PubChem identifier | 16078986 |
| SMILES | S=C(NCCCCNC(NC2=CC(N=C=S)=CC=C2)=S)NC1=CC(N=C=S)=CC=C1 |
| InChiKey | QOHNRGHTJPFMSL-UHFFFAOYSA-N |
Publications
These publications cite the use of MRS 2578 purchased from Hello Bio:
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Astrocytes extend serotonin-mediated effects on cortical inhibition
Wotton et al (2020) University of Saskatchewan : Thesis
Potent, selective P2Y6 receptor antagonist
Understanding purity and quality - a guide for life scientists