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Biological Data Biological description Selective ERα estrogen receptor agonist (Kd values are 2 and 1000 nM at ERα and ERβ respectively). Displays a 410-fold higher selectivity for ERα over ERβ. Shows neuroprotective effects. Active in vivo .
Solubility & Handling Storage instructions +4°C
Solubility overview Soluble in DMSO (100 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name 4,4',4''-(4-Propyl-[1H ]-pyrazole-1,3,5-triyl)tris phenol
Chemical structure
Molecular Formula C24 H22 N2 O3
PubChem identifier 6095481
SMILES CCCC1=C(N(NC1=C2C=CC(=O)C=C2)C3=CC=C(C=C3)O)C4=CC=C(C=C4)O
InChi InChI=1S/C24H22N2O3/c1-2-3-22-23(16-4-10-19(27)11-5-16)25-26(18-8-14-21(29)15-9-18)24(22)17-6-12-20(28)13-7-17/h4-15,25,28-29H,2-3H2,1H3
InChiKey UOSWGERPQQOSHS-UHFFFAOYSA-N
References for PPT References are publications that support the biological activity of the product
Pharmacokinetics of the estrogen receptor subtype-selective ligands, PPT and DPN: quantification using UPLC-ES/MS/MS. Sepehr E et al (2012) J Pharm Biomed Anal 71 : 119-26. The possible role of estrogen and selective estrogen receptor modulators in a rat model of Parkinson's disease. Baraka AM et al (2011) Life Sci 88(19-20) : 879-85. Estrogen receptor subtypes alpha and beta contribute to neuroprotection and increased Bcl-2 expression in primary hippocampal neurons. Zhao L et al (2004) Brain Res 1010(1-2) : 22-34.
Selective ERα estrogen receptor agonist
![PPT [263717-53-9] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb2499.png "PPT [263717-53-9]")
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