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SU 5402

(HB3133)
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Technical documents: Datasheet

Product overview

Name SU 5402
Purity >95%
Description Potent FGFR and VEGFR inhibitor. Attenuates integrin β4-induced neural stem cell differentiation.
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (2) Reviews References (3) Frequently bought together
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Biological Data

Biological description Potent FGFR and VEGFR inhibitor (IC50 values are 0.02, 0.03, 0.51 and >100 µM at VEGFR2, FGFR1, PDGFRβ and EGFR respectively). Attenuates integrin β4-induced neural stem cell differentiation. Shows potent in vitro and in vivo anticancer activity.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >95%
Chemical name 2-[(1,2-Dihydro-2-oxo-3H-indol-3-yl idene)methyl]-4-methyl-1H-pyrrole-3-propanoic acid
Molecular Weight 296.32
Chemical structure SU 5402 | [215543-92-3] Chemical Structure
Molecular Formula C17H16N2O3
CAS Number 215543-92-3
PubChem identifier 5289418
SMILES Cc1c[nH]c(c1CCC(=O)O)/C=C2/c3ccccc3NC2=O
InChi InChI=1S/C17H16N2O3/c1-10-9-18-15(11(10)6-7-16(20)21)8-13-12-4-2-3-5-14(12)19-17(13)22/h2-5,8-9,18H,6-7H2,1H3,(H,19,22)(H,20,21)/b13-8-
InChiKey JNDVEAXZWJIOKB-JYRVWZFOSA-N
MDL number MFCD08235144
Appearance Light orange to dark orange

References for SU 5402

References are publications that support the biological activity of the product

  • Rapid and efficient directed differentiation of human pluripotent stem cells into retinal pigmented epithelium.

    Buchholz et al (2013) Stem Cells Transl Med 2(5) : 384-93
    Read more (PubMedID: 23599499)

  • Neural stem cell differentiation is mediated by integrin beta4 in vitro.

    Su et al (2009) Int J Biochem Cell Biol 41(4) : 916-24
    Read more (PubMedID: 18834954)

  • Design, synthesis, and evaluations of substituted 3-[(3- or 4-carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as inhibitors of VEGF, FGF, and PDGF receptor tyrosine kinases.

    Sun et al (1999) J Med Chem 42(25) : 5120-30
    Read more (PubMedID: 10602697)

3 Item(s)

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Order: HB3133
Pack PriceQty
1mg
$72
5mg
$138
Potent FGFR and VEGFR inhibitor. Attenuates integrin β4-induced neural stem cell differentiation.
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