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Biological Data Biological description L-type Ca2+ channel blocker and adrenergic antagonist.
Shows various biological actions - increases FRZB expression and decreases Wnt/β-catenin signalling in osteoarthritis and shows cardioprotective, vasodilator, anti-arrhythmic, anti-oxidative stress actions.
Recently investigated as part of COVID-19 compound repurposing.
Solubility & Handling Storage instructions Room temperature
Solubility overview Soluble in water (50mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl) benzeneacetonitrile hydrochloride
Chemical structure
Molecular Formula C27 H38 N2 O4 .HCl
SMILES CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC.Cl
InChi InChI=1S/C27H38N2O4.ClH/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H
InChiKey DOQPXTMNIUCOSY-UHFFFAOYSA-N
References for Verapamil hydrochloride References are publications that support the biological activity of the product
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing Krogan et al (2020) Nature 7816 : 459-468 Comparative study of the effect of verapamil and vitamin D on iron overload-induced oxidative stress and cardiac structural changes in adult male rats. Abd Allah ES et al (2014) Pathophysiology : Verapamil protects against cartilage degradation in osteoarthritis by inhibiting Wnt/β-catenin signaling. Takamatsu A et al (2014) PLoS One 9(3) : e92699. Robust anti-arrhythmic efficacy of verapamil and flunarizine against dofetilide-induced TdP arrhythmias is based upon a shared and a different mode of action. Oros A et al (2010) Br J Pharmacol 161(1) : 162-75.
Publications
These publications cite the use of Verapamil hydrochloride purchased from Hello Bio:
Npas4 regulates medium spiny neuron physiology and gates cocaine-induced hyperlocomotion Lissek T et al (2021) EMBO Rep 22(12) : e51882
L-type Ca2+ channel blocker
![Verapamil hydrochloride [152-11-4] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1237.png "Verapamil hydrochloride [152-11-4]")
Understanding purity and quality - a guide for life scientists
