Product overview

Name Wortmannin
Alternative names SL-2052
Purity >99%
Description Potent, selective, irreversible PI3-K inhibitor
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Biological Data

Biological description Potent, selective, non-compettive and irreversible PI3-K inhibitor (IC50 = 2-4 nM). Also inhibits PI3-K related kinases and PLK1. Cell permeable. Shows variety of biological actions.

Solubility & Handling

Storage instructions -20°C (desiccate)
Solubility overview DMSO (50mM) and Ethanol (5mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Purity >99%
Chemical name (1S,6bR,9aS,11R,11bR) 11-(Acetyloxy)-1,6b,7,8,9a,10,11,11 b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-3H-f uro[4,3,2-de]indeno[4,5,-h]-2-h]-2-benzopyran-3,6, 9-trione
Molecular Weight 428.44
Molecular Formula C23H24O8
CAS Number 19545-26-7
PubChem identifier 3003565
SMILES O=C(C4=CO5)O[C@H](COC)[C@@]1(C)C4=C5C(C2=C1[C@H](OC(C)=O)C[C@@]3(C)C2CCC3=O)=O
InChiKey QDLHCMPXEPAAMD-ZGSWIPFCSA-N

References for Wortmannin

References are publications that support the biological activity of the product
  • Wortmannin, a widely used phosphoinositide 3-kinase inhibitor, also potently inhibits mammalian polo-like kinase.

    Liu et al (2005) Chem Biol 12(1) : 99-107
  • Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase.

    Ui et al (1995) Trends Biochem Sci 20(8) : 303-7
  • Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase.

    Powis et al (1994) Cancer Res 54(9) : 2419-23

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