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Z-VAD-(OMe)-FMK

(HB1319)
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Product overview

Name Z-VAD-(OMe)-FMK
Purity >95%
Description Irreversible, cell permeable, broad spectrum caspase inhibitor.
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3) Frequently bought together
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Z-VAD-(OMe)-FMK product vial image | Hello Bio
Z-VAD-(OMe)-FMK product vial image | Hello Bio

Z-VAD-(OMe)-FMK product vial image | Hello Bio

Z-VAD-(OMe)-FMK product vial image | Hello Bio

Biological Data

Biological description Irreversible, cell permeable, broad spectrum caspase inhibitor. Also inhibits PARP-1 cleavage and Fas-induced apoptosis. Hydrolysed by endogenous esterases into the biologically active form Z-VAD-FMK.

Solubility & Handling

Storage instructions -20°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >95%
Chemical name Benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone
Molecular Weight 467.48
Chemical structure Z-VAD-(OMe)-FMK [187389-52-2] Chemical Structure
Molecular Formula C22H30FN3O7
CAS Number 187389-52-2
PubChem identifier 5497174
SMILES C[C@@H](C(=O)N[C@@H](CC(=O)OC)C(=O)CF)NC(=O)[C@H](C(C)C)NC(=O)OCC1=CC=CC=C1
InChi InChI=1S/C22H30FN3O7/c1-13(2)19(26-22(31)33-12-15-8-6-5-7-9-15)21(30)24-14(3)20(29)25-16(17(27)11-23)10-18(28)32-4/h5-9,13-14,16,19H,10-12H2,1-4H3,(H,24,30)(H,25,29)(H,26,31)/t14-,16-,19-/m0/s1
InChiKey MIFGOLAMNLSLGH-QOKNQOGYSA-N
MDL number MFCD01074990
Appearance White solid

References for Z-VAD-(OMe)-FMK

References are publications that support the biological activity of the product

  • Amyloid precursor protein binding protein Fe65 is cleaved by caspases during DNA damage-induced apoptosis.

    Saeki K et al (2011) Biol Pharm Bull 34(2) : 290-4.
    Read more (PubMedID: 21415543)

  • A specific inhibitor of apoptosis decreases tissue injury after intestinal ischemia-reperfusion in mice.

    Farber A et al (1999) J Vasc Surg 30(4) : 752-60.
    Read more (PubMedID: 10514215)

  • Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32.

    Slee EA et al (1996) Biochem J 315 ( Pt 1) : 21-4.
    Read more (PubMedID: 8670109)

3 Item(s)

Grouped product items
Order: HB1319
Pack PriceQty
1mg
$212
5mg
$511
Irreversible, cell permeable, broad spectrum caspase inhibitor.
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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