1-O-Hexadecyl-2-O-acetyl-sn-glycerol

(HB0067)

Product overview

  • Name
    1-O-Hexadecyl-2-O-acetyl-sn-glycerol
  • Short description
    PKC inhibitor
  • Biological description
    Protein kinase C (PKC) inhibitor, acts as a diacylglycerol (DAG) antagonist. Synthetic precursor of platelet activating factor (PAF). Shows growth inhibitory actions against the promyelocytic leukemia cell line.
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Our products in action

Properties

  • Molecular Weight
    358.6
  • Chemical structure
    1-O-Hexadecyl-2-O-acetyl-sn-glycerol  [77133-35-8]
  • Molecular Formula
    C21H42O4
  • CAS Number
    77133-35-8

Storing and Using Your Product

  • Solubility overview
    soluble in ethanol or acetone

References for 1-O-Hexadecyl-2-O-acetyl-sn-glycerol

  • Activation of corticotropin-releasing factor 2 receptor inhibits Purkinje neuron P-type calcium currents via G(o)alpha-dependent PKC epsilon pathway.

    Tao J et al (2009) Cell Signal 21(9) : 1436-43.
    PubMedID: 19439178
  • Amyloid-beta42 signals tau hyperphosphorylation and compromises neuronal viability by disrupting alkylacylglycerophosphocholine metabolism.

    Ryan SD et al (2009) Proc Natl Acad Sci U S A 106(49) : 20936-41.
    PubMedID: 19926863
  • 1-O-alkyl-2-acetyl-sn-glycerol: a platelet-activating factor metabolite with biological activity in vascular smooth muscle cells.

    Stoll LL et al (1989) Cell Regul 1(1) : 13-25.
    PubMedID: 2519612
  • 1-0-Hexadecyl-2-acetyl-sn-glycerol stimulates differentiation of HL-60 human promyelocytic leukemia cells to macrophage-like cells.

    McNamara MJ et al (1984) Biochem Biophys Res Commun 122(2) : 824-30.
    PubMedID: 6590040

Reviews & Product Guides