10Z-Hymenialdisine

(HB1264)

Product overview

  • Name
    10Z-Hymenialdisine
  • Short description
    Pan kinase inhibitor. Potently inhibits MEK1, Cdk1, Cdk2, Cdk3 and Cdk5 and GSK-3β.
  • Biological description
    Pan kinase inhibitor. Potently inhibits MEK1 (IC50 = 6 nM at MEK-1) and GSK-3β. Also Inhibits IL-8, CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDk3/cyclin E and CDK5/p35 (IC50 values are 0.41 µM, 22, 70, 40, 100 and 28 nM respectively). Exhibits reduced activity at CDK4/cyclin D1 and CDK6/cyclin D2 (IC50 values are 600 and 700 nM respectively). Displays growth inhibitory properties towards tumor cells.
  • Biological action
    Inhibitor
  • Purity
    >97%
  • Citations

Properties

  • Chemical name
    (4Z)-4-(2-Amino-1,5-dihydro-5-oxo-4 H-imidazol-4-ylidene)-2-bromo-4,5,6,7-tetrahydropy rrolo[2,3-c]azepin-8(1H)-one
  • Molecular Weight
    324.13
  • Chemical structure
    10Z-Hymenialdisine  [82005-12-7]
  • Molecular Formula
    C11H10BrN5O2
  • CAS Number
    82005-12-7

Storing and Using Your Product

  • Storage instructions
    -20°C
  • Solubility overview
    soluble in DMSO (10mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for 10Z-Hymenialdisine

  • Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1).

    Tasdemir D et al (2002) J Med Chem 45(2) : 529-32.
    PubMedID: 11784156
  • Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent.

    Meijer L et al (2000) Chem Biol 7(1) : 51-63.
    PubMedID: 10662688

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