In my cart

You have no items in your shopping cart.



Product overview

  • Name
  • Short description
    Potent, selective JAK2 inhibitor
  • Biological description
    Potent and selective JAK2 tyrosine kinase inhibitor, inhibits autophosphorylation of JAK2. Shows apoptotic actions
  • Alternative names
    Hex; HBC; NSC 7908
  • Biological action
  • Citations


  • Chemical name
  • Molecular Weight
  • Chemical structure
    1,2,3,4,5,6-Hexabromocyclohexane  [1837-91-8]
  • Molecular Formula
  • CAS Number

Storing and Using Your Product

  • Storage instructions
    room temperature
  • Solubility overview
    soluble in DMSO (10mM, gentle warming)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for 1,2,3,4,5,6-Hexabromocyclohexane

  • Identification of 1,2,3,4,5,6-hexabromocyclohexane as a small molecule inhibitor of jak2 tyrosine kinase autophosphorylation [correction of autophophorylation].

    Sandberg EM et al (2005) J Med Chem 48(7) : 2526-33.
    PubMedID: 15801842
  • Growth hormone-stimulated insulin-like growth factor-1 expression in rainbow trout (Oncorhynchus mykiss) hepatocytes is mediated by ERK, PI3K-AKT, and JAK-STAT.

    Reindl KM et al (2011) Am J Physiol Regul Integr Comp Physiol 301(1) : R236-43.
    PubMedID: 21490369
  • Jak2 inhibition deactivates Lyn kinase through the SET-PP2A-SHP1 pathway, causing apoptosis in drug-resistant cells from chronic myelogenous leukemia patients.

    Samanta AK et al (2009) Oncogene 28(14) : 1669-81.
    PubMedID: 19234487
Support & Resources

Reviews & Product Guides