1,2,3,4,5,6-Hexabromocyclohexane

(HB1428)
Technical documents: Datasheet

Product overview

Name 1,2,3,4,5,6-Hexabromocyclohexane
Alternative names Hex; HBC; NSC 7908
Description Potent, selective JAK2 inhibitor
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Biological Data

Biological description Potent and selective JAK2 tyrosine kinase inhibitor, inhibits autophosphorylation of JAK2. Shows apoptotic actions

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO (10mM, gentle warming)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Chemical name 1,2,3,4,5,6-Hexabromocyclohexane
Molecular Weight 557.54
Chemical structure 1,2,3,4,5,6-Hexabromocyclohexane  [1837-91-8] Chemical Structure
Molecular Formula C6H6Br6
CAS Number 1837-91-8
PubChem identifier 74603
SMILES BrC1C(C(C(C(C1Br)Br)Br)Br)Br
InChiKey QFQZKISCBJKVHI-UHFFFAOYSA-N

References for 1,2,3,4,5,6-Hexabromocyclohexane

References are publications that support the biological activity of the product
  • Growth hormone-stimulated insulin-like growth factor-1 expression in rainbow trout (Oncorhynchus mykiss) hepatocytes is mediated by ERK, PI3K-AKT, and JAK-STAT.

    Reindl KM et al (2011) Am J Physiol Regul Integr Comp Physiol 301(1) : R236-43.
  • Jak2 inhibition deactivates Lyn kinase through the SET-PP2A-SHP1 pathway, causing apoptosis in drug-resistant cells from chronic myelogenous leukemia patients.

    Samanta AK et al (2009) Oncogene 28(14) : 1669-81.
  • Identification of 1,2,3,4,5,6-hexabromocyclohexane as a small molecule inhibitor of jak2 tyrosine kinase autophosphorylation [correction of autophophorylation].

    Sandberg EM et al (2005) J Med Chem 48(7) : 2526-33.

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