12(S)-HPETE

(HB0060)

Product overview

  • Name
    12(S)-HPETE
  • Short description
    CaM kinase II inhibitor
  • Biological description
    Endogenous CAMKII inhibitor. Shows many biological actions. Suppresses platelet cyclooxygenase to suppress thromboxane and inhibits platelet activation. Shows neurotoxic actions.
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    12S-hydroperoxy-5Z,8Z,10E,14Z-eicosatetraenoic acid
  • Molecular Weight
    336.5
  • Chemical structure
    12(S)-HPETE  [71774-10-2]
  • Molecular Formula
    C20H32O4
  • CAS Number
    71774-10-2
  • PubChem identifier
    656507
  • SMILES
    CCCCCC=CCC(C=CC=CCC=CCCCC(=O)O)OO

Storing and Using Your Product

  • Solubility overview
    soluble in water (0.8mg/ml, at 25 oC) or DMSO

References for 12(S)-HPETE

  • 12-hydroperoxyeicosatetraenoic acid inhibits main platelet functions by activation of soluble guanylate cyclase.

    Brüne B et al (1991) Mol Pharmacol 39(5) : 671-8.
    PubMedID: 1674588
  • Inhibition of renin release by arachidonic acid metabolites, 12(s)-HPETE and 12-HETE: role of TRPV1 channels.

    Xie C et al (2011) Endocrinology 152(10) : 3811-9.
    PubMedID: 21846804
  • Interactions between CB(1) receptors and TRPV1 channels mediated by 12-HPETE are cytotoxic to mesencephalic dopaminergic neurons.

    Kim SR et al (2008) Br J Pharmacol 155(2) : 253-64.
    PubMedID: 18552868

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