17 α-Estradiol

(HB2493)

Product overview

  • Name
    17 α-Estradiol
  • Short description
    Estrogen receptor (ER) ligand. Non-feminizing estrogen.
  • Biological description
    Endogenous estrogen receptor (ER) ligand (Ki values are 0.2 and 1.2 nM at ERα and ERβ respectively). Non-feminizing estrogen. Shows antioxidant, anti-neurodegenerative and neuroprotective effects. Orally active.
  • Alternative names
    Estradiol|Alfatradiol|EST
  • Biological action
    Other
  • Purity
    >96%
  • Citations

Properties

  • Chemical name
    (17α)-Estra-1,3,5(10)-triene-3,17-diol
  • Molecular Weight
    272.38
  • Chemical structure
    17 α-Estradiol
  • Molecular Formula
    C18H24O2
  • CAS Number
    57-91-0

Storing and Using Your Product

  • Storage instructions
    room temperature
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for 17 α-Estradiol

  • Acarbose, 17-?±-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males.

    Harrison DE et al (2014) Aging Cell 13(2) : 273-82.
    PubMedID: 24245565
  • Effects of 17 beta-estradiol and its isomer 17 alpha-estradiol on learning in rats with chronic cholinergic deficiency in the brain.

    Lermontova NN et al (2000) Bull Exp Biol Med 129(5) : 442-4.
    PubMedID: 10977945
  • 17 alpha-estradiol exerts neuroprotective effects on SK-N-SH cells.

    Green PS et al (1997) J Neurosci 17(2) : 511-5.
    PubMedID: 8987774
  • Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta.

    Kuiper GG et al (1997) Endocrinology 138(3) : 863-70.
    PubMedID: 9048584

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