17 β-Estradiol

(HB2494)

Product overview

  • Name
    17 β-Estradiol
  • Short description
    Estrogen receptor (ER) agonist
  • Biological description
    Estrogen receptor (ER) agonist (Ki values are 0.13 and 0.12 nM at ERα and ERβ respectively). Also shows activity at GPR30 receptors (Ki = 6 nM). Endogenous hormone. Shows neuroprotective and antioxidant effects.
  • Alternative names
    Estradiol|E2
  • Biological action
    Agonist
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    (8R,9S,13S,14S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
  • Molecular Weight
    272.38
  • Chemical structure
    17 β-Estradiol [50-28-2]
  • Molecular Formula
    C18H24O2
  • CAS Number
    50-28-2
  • PubChem identifier
    5757
  • SMILES
    C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCC4=C3C=CC(=C4)O
  • InChi
    InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1
  • InChiKey
    VOXZDWNPVJITMN-ZBRFXRBCSA-N
  • MDL number
    MFCD00003693

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Solubility overview
    Soluble in DMSO (100 mM) and in ethanol (75 mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for 17 β-Estradiol

  • 17-beta estradiol protects neurons from oxidative stress-induced cell death in vitro.

    Behl C et al (1995) Biochem Biophys Res Commun 216(2) : 473-82.
    PubMedID: 7488136
  • Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells.

    Thomas P et al (2005) Endocrinology 146(2) : 624-32.
    PubMedID: 15539556
  • Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta.

    Kuiper GG et al (1997) Endocrinology 138(3) : 863-70.
    PubMedID: 9048584
  • The ins and outs of GPR30: a transmembrane estrogen receptor.

    Prossnitz ER et al (2008) J Steroid Biochem Mol Biol 109(3-5) : 350-3.
    PubMedID: 18406603

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