1-Naphthyl PP1

(HB0066)

Product overview

  • Name
    1-Naphthyl PP1
  • Short description
    Potent, selective src family kinase inhibitor
  • Biological description
    Potent and selective src family kinase inhibitor, including v-Src and c-Fyn. Selective for analogs rather than wild-type kinase (IC50 values are 1.5 nM and 1 µM for v-Src analog versus wild-type). Also inhibits c-AbI and Aurora A kinase and is a potent PKD inhibitor. Shows anti-cancer actions. Cell-permeable.
  • Biological action
    Inhibitor
  • Purity
    >99%
  • Our products in action

Properties

  • Molecular Weight
    317.39
  • Chemical structure
    1-Naphthyl PP1  [221243-82-9]
  • Molecular Formula
    C19H19N5
  • CAS Number
    221243-82-9
  • PubChem identifier
    4877
  • SMILES
    CC(C)(C)N1C2=C(C(=N1)C3=CC=CC4=CC=CC=C43)C(=NC=N2)N

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    soluble in DMSO (20mg/ml) or chloroform
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for 1-Naphthyl PP1

  • A chemical switch for inhibitor-sensitive alleles of any protein kinase.

    Bishop AC et al (2000) Nature 407(6802) : 395-401.
    PubMedID: 11014197
  • New pyrazolopyrimidine inhibitors of protein kinase d as potent anticancer agents for prostate cancer cells.

    Tandon M et al (2013) PLoS One 8(9) : e75601.
    PubMedID: 24086585
  • Aurora A is involved in central spindle assembly through phosphorylation of Ser 19 in P150Glued.

    Reboutier D et al (2013) J Cell Biol 201(1) : 65-79.
    PubMedID: 23547029

Reviews & Product Guides