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1-Naphthyl PP1


Product overview

  • Name
    1-Naphthyl PP1
  • Short description
    Potent, selective src family kinase inhibitor
  • Biological description
    Potent and selective src family kinase inhibitor, including v-Src and c-Fyn. Selective for analogs rather than wild-type kinase (IC50 values are 1.5 nM and 1 µM for v-Src analog versus wild-type). Also inhibits c-AbI and Aurora A kinase and is a potent PKD inhibitor. Shows anti-cancer actions. Cell-permeable.
  • Biological action
  • Purity
  • Citations


  • Molecular Weight
  • Chemical structure
    1-Naphthyl PP1  [221243-82-9]
  • Molecular Formula
  • CAS Number
  • PubChem identifier

Storing and Using Your Product

  • Storage instructions
  • Solubility overview
    soluble in DMSO (20mg/ml) or chloroform
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for 1-Naphthyl PP1

  • A chemical switch for inhibitor-sensitive alleles of any protein kinase.

    Bishop AC et al (2000) Nature 407(6802) : 395-401.
    PubMedID: 11014197
  • New pyrazolopyrimidine inhibitors of protein kinase d as potent anticancer agents for prostate cancer cells.

    Tandon M et al (2013) PLoS One 8(9) : e75601.
    PubMedID: 24086585
  • Aurora A is involved in central spindle assembly through phosphorylation of Ser 19 in P150Glued.

    Reboutier D et al (2013) J Cell Biol 201(1) : 65-79.
    PubMedID: 23547029
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