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Data

Product overview

  • Name
    2-APB
  • Short description
    IP3 receptor and store-operated channels (SOC) channel antagonist
  • Biological description

    2-APB is a membrane permeable IP3 (inositol 1,4,5-trisphosphate) receptor antagonist (IC50 = 42µM) and store-operated Ca2+ channel (SOC) antagonist.


    2-APB also blocks SERCA (IC50 = 91µM) and modulates some TRP channels (inhibits TRPC1, TRPC3 and TRPC5, activates TRPV1, TRPV2 and TRPV3 and shows dual activity on TRPM7 channels).


    2-APB is an effector of store-operated Ca2+ entry (SOCE) which potentiates store-operated Ca2+ entry at 1-5 µM and inhibits it at >30 µM.


    2-APB has also been shown to increase excitability in pyramidal neurons.

  • Alternative names
    2-aminoethoxydiphenyl borate
  • Biological action
    Antagonist
  • Citations

Properties

  • Chemical name
    2-Aminoethoxydiphenylborane
  • Molecular Weight
    225.1
  • Chemical structure
    2-APB [524-95-8]
  • Molecular Formula
    C14H16BNO
  • CAS Number
    524-95-8
  • PubChem identifier
    1598
  • SMILES
    NCCOB(C1=CC=CC=C1)C1=CC=CC=C1
  • InChi
    InChI=1S/C14H16BNO/c16-11-12-17-15(13-7-3-1-4-8-13)14-9-5-2-6-10-14/h1-10H,11-12,16H2
  • InChiKey
    BLZVCIGGICSWIG-UHFFFAOYSA-N
  • MDL number
    MFCD00014823
  • Appearance
    White solid

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Solubility overview
    DMSO (100mM) and ethanol (10mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for 2-APB

  • 2-Aminoethoxydiphenyl-borate (2-APB) increases excitability in pyramidal neurons.

    Hagenston et al (2009) Cell Calcium 45(3) : 310-7
    PubMedID: 19100621
  • 2-aminoethoxydiphenyl borate (2-APB) is a reliable blocker of store-operated Ca2+ entry but an inconsistent inhibitor of InsP3-induced Ca2+ release.

    Bootman et al (2002) FASEB J 16(10) : 1145-50
    PubMedID: 12153982
  • Molecular mechanism of 2-APB-induced Ca²⁺ influx in external acidification in PC12.

    Takahashi et al (2014) Exp Cell Res 232(2) : 337-45
    PubMedID: 24630903
  • 2APB, 2-aminoethoxydiphenyl borate, a membrane-penetrable modulator of Ins(1,4,5)P3-induced Ca2+ release.

    Maruyama et al (1997) J Biochem 122(3) : 498-505
    PubMedID: 9348075
  • Inhibition of the transient receptor potential cation channel TRPM2 by 2-aminoethoxydiphenyl borate (2-APB).

    Togashi et al (2008) Br J Pharmacol 153(6) : 1324-30
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