2-Chloroadenosine (CADO)

(HB2844)

Product overview

  • Name
    2-Chloroadenosine (CADO)
  • Short description
    Adenosine receptor agonist
  • Biological description

    Analog of adenosine. Adenosine receptor agonist (Ki values are 300, 80 and 1900 nM at A1, A2A and A3 receptors resepectively. Shows anticonvulsant activity. Active in vivo.

    Also inhibits the induction of long-term potentiation (LTP).
  • Alternative names
    2-CADO
  • Biological action
    Agonist
  • Purity
    >99%
  • Citations

Properties

  • Chemical name
    6-Amino-2-chloropurine riboside
  • Molecular Weight
    301.69
  • Chemical structure
    2-Chloroadenosine [146-77-0]
  • Molecular Formula
    C10H12ClN5O4
  • CAS Number
    146-77-0
  • PubChem identifier
    8974
  • SMILES
    C1=NC2=C(N1[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O)N=C(N=C2N)Cl
  • InChi
    InChI=1S/C10H12ClN5O4/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(19)5(18)3(1-17)20-9/h2-3,5-6,9,17-19H,1H2,(H2,12,14,15)/t3-,5-,6-,9-/m1/s1
  • InChiKey
    BIXYYZIIJIXVFW-UUOKFMHZSA-N
  • MDL number
    MFCD00005734
  • Appearance
    White solid

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    Soluble in water (25mM) and in DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for 2-Chloroadenosine (CADO)

  • The protective effect of 2-chloroadenosine against the development of amygdala kindling and on amygdala-kindled seizures.

    Abdul-Ghani et al (1997) Eur J Pharmacol. 326(1) : 7-14
    PubMedID: 9178649
  • Pharmacokinetic-haemodynamic relationships of 2-chloroadenosine at adenosine A1 and A2a receptors in vivo.

    Mathoot et al (1996) Br J Pharmacol 118(2) : 369-77
    PubMedID: 8735640
  • Effects of 2-chloroadenosine on cortical epileptic afterdischarges in immature rats.

    Pometlova et al (2010) Pharmacol Rep 62(1) : 62-7
    PubMedID: 20360616
  • 2-Chloroadenosine decreases long-term potentiation in the hippocampal CA1 area of the rat.

    de Mendonca et al (1990) Neurosci Lett 118(1) : 107-11
    PubMedID: 2259460

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