2,4-Diamino-6-hydroxypyrimidine

(HB0070)

Product overview

  • Name
    2,4-Diamino-6-hydroxypyrimidine
  • Short description
    GTP cyclohydrolase I (GCH1) inhibitor
  • Biological description
    GTP cyclohydrolase I (GCH1) inhibitor. Decreases tetrahydrobiopterin (BH4) synthesis and suppresses NOS activity. Also causes a decrease in vascular cell adhesion molecule 1 (VCAM-1) cells in response to TNF-α and IFN-γ.
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    DAHP
  • Molecular Weight
    126.12
  • Chemical structure
    2,4-Diamino-6-hydroxypyrimidine  [56-06-4]
  • Molecular Formula
    C4H6N4O
  • CAS Number
    56-06-4
  • PubChem identifier
    2944
  • SMILES
    C1(=CC(N=C(N1[H])N([H])[H])=O)N([H])[H]

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    soluble in DMSO or water

References for 2,4-Diamino-6-hydroxypyrimidine

  • GTP cyclohydrolase I inhibition by the prototypic inhibitor 2, 4-diamino-6-hydroxypyrimidine. Mechanisms and unanticipated role of GTP cyclohydrolase I feedback regulatory protein.

    Xie L et al (1998) J Biol Chem 273(33) : 21091-8.
    PubMedID: 9694862
  • 2,4-Diamino-6-hydroxypyrimidine (DAHP) suppresses cytokine-induced VCAM-1 expression on the cell surface of human umbilical vein endothelial cells in a BH(4)-independent manner.

    Ikemoto K et al (2008) Biochim Biophys Acta 1780(7-8) : 960-5.
    PubMedID: 18423409
  • The mechanism of potent GTP cyclohydrolase I inhibition by 2,4-diamino-6-hydroxypyrimidine: requirement of the GTP cyclohydrolase I feedback regulatory protein.

    Kolinsky MA et al (2004) J Biol Chem 279(39) : 40677-82.
    PubMedID: 15292175

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