2,4-Diamino-6-hydroxypyrimidine

(HB0070)
Technical documents: CoA Datasheet

Product overview

Name 2,4-Diamino-6-hydroxypyrimidine
Purity >98%
Description GTP cyclohydrolase I (GCH1) inhibitor
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Biological Data

Biological description GTP cyclohydrolase I (GCH1) inhibitor. Decreases tetrahydrobiopterin (BH4) synthesis and suppresses NOS activity. Also causes a decrease in vascular cell adhesion molecule 1 (VCAM-1) cells in response to TNF-α and IFN-γ.

Solubility & Handling

Storage instructions +4°C
Solubility overview

Soluble in DMSO (100 mM), and in water (50 mM)

Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name DAHP
Molecular Weight 126.12
Chemical structure 2,4-Diamino-6-hydroxypyrimidine  [56-06-4] Chemical Structure
Molecular Formula C4H6N4O
CAS Number 56-06-4
PubChem identifier 2944
SMILES C1(=CC(N=C(N1[H])N([H])[H])=O)N([H])[H]
InChi InChI=1S/C4H6N4O/c5-2-1-3(9)8-4(6)7-2/h1H,(H5,5,6,7,8,9)
InChiKey SWELIMKTDYHAOY-UHFFFAOYSA-N
MDL number MFCD00006098

References for 2,4-Diamino-6-hydroxypyrimidine

References are publications that support the biological activity of the product
  • 2,4-Diamino-6-hydroxypyrimidine (DAHP) suppresses cytokine-induced VCAM-1 expression on the cell surface of human umbilical vein endothelial cells in a BH(4)-independent manner.

    Ikemoto K et al (2008) Biochim Biophys Acta 1780(7-8) : 960-5.
  • The mechanism of potent GTP cyclohydrolase I inhibition by 2,4-diamino-6-hydroxypyrimidine: requirement of the GTP cyclohydrolase I feedback regulatory protein.

    Kolinsky MA et al (2004) J Biol Chem 279(39) : 40677-82.
  • GTP cyclohydrolase I inhibition by the prototypic inhibitor 2, 4-diamino-6-hydroxypyrimidine. Mechanisms and unanticipated role of GTP cyclohydrolase I feedback regulatory protein.

    Xie L et al (1998) J Biol Chem 273(33) : 21091-8.

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