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2,5-Dimethyl-celecoxib

(HB3717)
Data

Product overview

  • Name
    2,5-Dimethyl-celecoxib
  • Short description
    Shows no COX-2 inhibitory function. Analog of celecoxib.
  • Biological description
    Close structural analog of the selective cyclooxygenase-2 (COX-2) inhibitor celecoxib, that lacks COX-2 inhibitory function. Anti-proliferative, anti-tumorigenic and anti-angiogenic. Potent apoptosis inducer in many cancer cell lines. Down-regulates the expression of survivin, cyclins, MMPs and inhibits cyclin-dependent kinase activity. Modulates PDK-1, AKT, GSK3beta, p70 S6K, PKA and MAPKAP-K1alpha.Reduces phosphorylation of ERK1/2 but not AKT T-308 or AKT S-473. Increases intracellular free calcium levels and potently triggers the endoplasmatic reticulum stress response (ESR), activating ER stress-associated proteins GRP78/BiP, CHOP/GADD153 and caspase-4.
  • Purity
    >99%
  • Citations

Properties

  • Chemical name
    2,5-Dimethylcelecoxib
  • Molecular Weight
    395.4
  • Chemical structure
    2,5-Dimethyl-celecoxib [457639-26-8]
  • CAS Number
    457639-26-8
  • InChiKey
    NTFOSUUWGCDXEF-UHFFFAOYSA-N
  • Appearance
    White solid

Storing and Using Your Product

  • Storage instructions
    room temperature
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
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