3-Deazaneplanocin A hydrochloride

(HB1416)

Product overview

  • Name
    3-Deazaneplanocin A hydrochloride
  • Short description
    Histone methyltransferase inhibitor. Enhances Oct4 expression in chemically-induced pluripotent stem cells.
  • Biological description
    Histone methyltransferase inhibitor. Inhibits S-adenosylhomocysteine hydrolase (SAH) and EZH2 protein expression. Also enhances Oct4 expression in chemically-induced pluripotent stem cells. Shows anti-cancer and antiviral actions.
  • Alternative names
    DZNep
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    (1S,2R,5R)-5-(4-Amino-1H-imidazo[4, 5-c]pyridin-1-yl)-3-(hydroxymethyl)-3-cyclopentene -1,2-diol hydrochloride
  • Molecular Weight
    298.73
  • Chemical structure
    3-Deazaneplanocin A hydrochloride  [120964-45-6]
  • Molecular Formula
    C12H14N4O3.HCl
  • CAS Number
    120964-45-6

Storing and Using Your Product

  • Storage instructions
    -20°C
  • Solubility overview
    soluble in water (10mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for 3-Deazaneplanocin A hydrochloride

  • Synthesis of 3-deazaneplanocin A, a powerful inhibitor of S-adenosylhomocysteine hydrolase with potent and selective in vitro and in vivo antiviral activities.

    Tseng CK et al (1989) J Med Chem 32(7) : 1442-6.
    PubMedID: 2544721
  • 3-Deazaneplanocin A (DZNep), an inhibitor of the histone methyltransferase EZH2, induces apoptosis and reduces cell migration in chondrosarcoma cells.

    Girard N et al (2014) PLoS One 9(5) : e98176.
    PubMedID: 24852755
  • Inhibition of histone methyltransferase EZH2 depletes leukemia stem cell of mixed lineage leukemia fusion leukemia through upregulation of p16.

    Ueda K et al (2014) Cancer Sci 105(5) : 512-9.
    PubMedID: 24612037