3-Deazaneplanocin A hydrochloride

(HB1416)
Technical documents: Datasheet

Product overview

Name 3-Deazaneplanocin A hydrochloride
Alternative names DZNep
Purity >98%
Description Histone methyltransferase inhibitor. Enhances Oct4 expression in chemically-induced pluripotent stem cells.
Write Your Own Review
You're reviewing:3-Deazaneplanocin A hydrochloride
Rate this item:

Biological Data

Biological description Histone methyltransferase inhibitor. Inhibits S-adenosylhomocysteine hydrolase (SAH) and EZH2 protein expression. Also enhances Oct4 expression in chemically-induced pluripotent stem cells. Shows anti-cancer and antiviral actions.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in water (10mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

=
x
x
More Info

Dilution

x
=
x
More Info

Chemical Data

Purity >98%
Chemical name (1S,2R,5R)-5-(4-Amino-1H-imidazo[4, 5-c]pyridin-1-yl)-3-(hydroxymethyl)-3-cyclopentene -1,2-diol hydrochloride
Molecular Weight 298.73
Chemical structure 3-Deazaneplanocin A hydrochloride  [120964-45-6] Chemical Structure
Molecular Formula C12H14N4O3.HCl
CAS Number 120964-45-6
PubChem identifier 14563109
SMILES OCC([C@@H](O)[C@H]3O)=C[C@H]3N2C=NC1=C(N)N=CC=C12.Cl
InChiKey UNSKMHKAFPRFTI-FDKLLANESA-N

References for 3-Deazaneplanocin A hydrochloride

References are publications that support the biological activity of the product
  • 3-Deazaneplanocin A (DZNep), an inhibitor of the histone methyltransferase EZH2, induces apoptosis and reduces cell migration in chondrosarcoma cells.

    Girard N et al (2014) PLoS One 9(5) : e98176.
  • Inhibition of histone methyltransferase EZH2 depletes leukemia stem cell of mixed lineage leukemia fusion leukemia through upregulation of p16.

    Ueda K et al (2014) Cancer Sci 105(5) : 512-9.
  • Synthesis of 3-deazaneplanocin A, a powerful inhibitor of S-adenosylhomocysteine hydrolase with potent and selective in vitro and in vivo antiviral activities.

    Tseng CK et al (1989) J Med Chem 32(7) : 1442-6.

3 Item(s)