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3-Methyladenine

(HB2267)
Data

Product overview

  • Name
    3-Methyladenine
  • Short description
    PI-3K inhibitor
  • Biological description
    Phosphoinositide 3-kinase (PI-3K) inhibitor. Inhibits autophagy, modulates endosomal membrane trafficking and stimulates adipocyte PKA-dependent lipolysis. May potentiate the action of anticancer drugs.
  • Biological action
    Inhibitor
  • Purity
    >99%
  • Citations

Properties

  • Chemical name
    3-Methyl-3H-purin-6-amine
  • Molecular Weight
    149.15
  • Molecular Formula
    C6H7N5
  • CAS Number
    5142-23-4

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for 3-Methyladenine

  • 3-Methyladenine, an inhibitor of autophagy, has multiple effects on metabolism.

    Caro et al (1988) Eur J Biochem 175(2) : 325-9
    PubMedID: 3402459
  • 3-Methyladenine induces cell death and its interaction with chemotherapeutic drugs is independent of autophagy.

    Sheng et al (2013) Biochem Biophys Res Commun. 432(1) : 5-9
    PubMedID: 23395679
  • 3-Methyladenine specifically inhibits retrograde transport of cation-independent mannose 6-phosphate/insulin-like growth factor II receptor from the early endosome to the TGN.

    Hirosako et al (2004) Biochem Biophys Res Commun 316(3) : 845-52
    PubMedID: 15033478
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