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Product overview

  • Name
  • Short description
    Protein tyrosine phosphatase inhibitor
  • Biological description
    Protein tyrosine phosphatase inhibitor (IC50 = 18 µM). Inhibits SHP-1 and suppresses myeloid differentiation in acute promyelocytic leukemia. Enhances neurite formation induced by NGF in PC12h cells.
  • Biological action
  • Purity
  • Citations


  • Chemical name
  • Molecular Weight
  • Chemical structure
  • Molecular Formula

Storing and Using Your Product

  • Storage instructions
  • Solubility overview
    soluble in DMSO (18mg/ml) or water
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for 3,4-Dephostatin

  • Inhibition of ATRA-induced myeloid differentiation in acute promyelocytic leukemia by a new protein tyrosine phosphatase inhibitor, 3,4-dephostatin.

    Uesugi Y et al (2000) J Exp Clin Cancer Res 19(3) : 363-6.
    PubMedID: 11144530
  • Enhancement or induction of neurite formation by a protein tyrosine phosphatase inhibitor, 3,4-dephostatin, in growth factor-treated PC12h cells.

    Fujiwara S et al (1997) Biochem Biophys Res Commun 238(1) : 213-7.
    PubMedID: 9299481
  • Resistance to phorbol 12-myristate 13-acetate-induced cell growth arrest in an HL60 cell line chronically exposed to a glutathione S-transferase pi inhibitor.

    Gatã? L et al (2003) Biochem Pharmacol 65(10) : 1611-22.
    PubMedID: 12754097
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