4-Aminopyridine (4-AP)
(HB1073)
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Code: HB0225
Pack: 1mg,10mg,50mg,100mg,50mM (add 1ml water),100mM (add 1ml water)
Code: HB1035
Pack: 1mg
Code: HB1088
Pack: 1g,5g
4-Aminopyridine (4-AP)
(HB1073)- Data
- Support & Resources
Product overview
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Name
4-Aminopyridine (4-AP)
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Short description
Non-selective voltage gated K+ channel blocker
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Biological description
4-Aminopyridine (4-AP) is a non-selective voltage gated K+ channel blocker which blocks Kv1.1 and Kv1.2 channels (IC50 values are 170 and 230 µM respectively).
4-aminopyridine facilitates synaptic and neuromuscular transmission.
4-AP shows proconvulsive actions.
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Alternative names
4-AP, 4AP
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Biological action
Blocker
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Purity
>99%
- Citations
Properties
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Chemical name
4-Aminopyridine
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Molecular Weight
94.12
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Chemical structure
![4-Aminopyridine [504-24-5]](data:image/gif;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs= "4-Aminopyridine [504-24-5]")
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Molecular Formula
C5H6N2
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CAS Number
504-24-5
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PubChem identifier
1727
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SMILES
C1=CN=CC=C1N
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InChi
InChI=1S/C5H6N2/c6-5-1-3-7-4-2-5/h1-4H,(H2,6,7)
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InChiKey
NUKYPUAOHBNCPY-UHFFFAOYSA-N
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MDL number
MFCD00006439
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Appearance
White solid
![4-Aminopyridine [504-24-5]](https://www.hellobio.com/media/catalog/product/cache/1/image/9df78eab33525d08d6e5fb8d27136e95/h/b/hb1073.png "4-Aminopyridine [504-24-5]")
Storing and Using Your Product
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Storage instructions
Room temperature
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Solubility overview
Soluble in water (100mM) and in DMSO (100 mM)
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Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for 4-Aminopyridine (4-AP)
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4-Aminopyridine ameliorates mobility but not disease course in an animal model of multiple sclerosis.
Göbel K et al (2013) Exp Neurol 248 : 62-71.PubMedID: 23748135 -
Identification of selective inhibitors of the potassium channel Kv1.1-1.2((3)) by high-throughput virtual screening and automated patch clamp.
Wacker SJ et al (2012) ChemMedChem 7(10) : 1775-83.PubMedID: 22473914 -
Temporal lobe epileptiform activity following systemic administration of 4-aminopyridine in rats.
Lévesque M et al (2013) Epilepsia 54(4) : 596-604.PubMedID: 23521339 -
Different state dependencies of 4-aminopyridine binding to rKv1.4 and rKv4.2: role of the cytoplasmic halves of the fifth and sixth transmembrane segments.
Tseng GN (1999) J Pharmacol Exp Ther 290(2) : 569-77.PubMedID: 10411564
Reviews & Product Guides
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