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4-Aminopyridine (4-AP)

(HB1073)
Data

Product overview

  • Name
    4-Aminopyridine (4-AP)
  • Short description
    Non-selective voltage gated K+ channel blocker
  • Biological description

    4-Aminopyridine (4-AP) is a non-selective voltage gated K+ channel blocker which blocks Kv1.1 and Kv1.2 channels (IC50 values are 170 and 230 µM respectively).

    4-aminopyridine facilitates synaptic and neuromuscular transmission.

    4-AP shows proconvulsive actions.

  • Alternative names
    4-AP, 4AP
  • Biological action
    Blocker
  • Purity
    >99%
  • Citations

Properties

  • Chemical name
    4-Aminopyridine
  • Molecular Weight
    94.12
  • Chemical structure
    4-Aminopyridine  [504-24-5]
  • Molecular Formula
    C5H6N2
  • CAS Number
    504-24-5
  • PubChem identifier
    1727
  • SMILES
    C1=CN=CC=C1N
  • InChi
    InChI=1S/C5H6N2/c6-5-1-3-7-4-2-5/h1-4H,(H2,6,7)
  • InChiKey
    NUKYPUAOHBNCPY-UHFFFAOYSA-N
  • MDL number
    MFCD00006439
  • Appearance
    White solid

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Solubility overview
    Soluble in water (100mM) and in DMSO (100 mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for 4-Aminopyridine (4-AP)

  • 4-Aminopyridine ameliorates mobility but not disease course in an animal model of multiple sclerosis.

    Göbel K et al (2013) Exp Neurol 248 : 62-71.
    PubMedID: 23748135
  • Identification of selective inhibitors of the potassium channel Kv1.1-1.2((3)) by high-throughput virtual screening and automated patch clamp.

    Wacker SJ et al (2012) ChemMedChem 7(10) : 1775-83.
    PubMedID: 22473914
  • Temporal lobe epileptiform activity following systemic administration of 4-aminopyridine in rats.

    Lévesque M et al (2013) Epilepsia 54(4) : 596-604.
    PubMedID: 23521339
  • Different state dependencies of 4-aminopyridine binding to rKv1.4 and rKv4.2: role of the cytoplasmic halves of the fifth and sixth transmembrane segments.

    Tseng GN (1999) J Pharmacol Exp Ther 290(2) : 569-77.
    PubMedID: 10411564
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