4-Aminopyridine (4-AP)

(HB1073)

Order: HB1073

Pack	Price	Qty
100mg	$40

(HB1073)

Data

Product overview

Name
4-Aminopyridine (4-AP)
Short description
Non-selective voltage gated K⁺ channel blocker
Biological description

4-Aminopyridine (4-AP) is a non-selective voltage gated K⁺ channel blocker which blocks K_v1.1 and K_v1.2 channels (IC₅₀ values are 170 and 230 µM respectively).

4-aminopyridine facilitates synaptic and neuromuscular transmission.

4-AP shows proconvulsive actions.
Alternative names
4-AP, 4AP
Biological action
Blocker
Purity
>99%
Citations
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Storage instructions
Room temperature
Solubility overview
Soluble in water (100mM) and in DMSO (100 mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

4-Aminopyridine ameliorates mobility but not disease course in an animal model of multiple sclerosis.

Göbel K et al (2013) Exp Neurol 248 : 62-71.
PubMedID: 23748135
Identification of selective inhibitors of the potassium channel Kv1.1-1.2((3)) by high-throughput virtual screening and automated patch clamp.

Wacker SJ et al (2012) ChemMedChem 7(10) : 1775-83.
PubMedID: 22473914
Temporal lobe epileptiform activity following systemic administration of 4-aminopyridine in rats.

Lévesque M et al (2013) Epilepsia 54(4) : 596-604.
PubMedID: 23521339
Different state dependencies of 4-aminopyridine binding to rKv1.4 and rKv4.2: role of the cytoplasmic halves of the fifth and sixth transmembrane segments.

Tseng GN (1999) J Pharmacol Exp Ther 290(2) : 569-77.
PubMedID: 10411564

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