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Product overview

  • Name
  • Short description
    Selective M3 receptor antagonist
  • Biological description
    Selective M3 muscarinic receptor antagonist. Blocks [3H]-scopolamine binding to muscle cells expressing M3 and M2 (IC50 values are 0.4 nM and 15 µM respectively).
  • Biological action
  • Purity
  • Citations


  • Chemical name
    1,1-Dimethyl-4-diphenylacetoxypiperidinium iodide
  • Molecular Weight
  • Chemical structure
    4-DAMP  [1952-15-4]
  • Molecular Formula
  • CAS Number
  • PubChem identifier
  • InChiKey

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Solubility overview
    Soluble in DMSO (25mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for 4-DAMP

  • Differential coupling of muscarinic m2 and m3 receptors to adenylyl cyclases V/VI in smooth muscle. Concurrent M2-mediated inhibition via Galphai3 and m3-mediated stimulation via Gbetagammaq.

    Murthy KS et al (1997) J Biol Chem 272(34) : 21317-24.
    PubMedID: 9261144
  • The use of a modified [3H]4-DAMP radioligand binding assay with increased selectivity for muscarinic M3 receptor shows that cortical CHRM3 levels are not altered in mood disorders.

    Jeon WJ et al (2013) Prog Neuropsychopharmacol Biol Psychiatry 47 : 7-12.
    PubMedID: 23962466
  • Regional binding of 4-diphenylacetoxy-N-methylpiperidine methobromide (4-DAMP) to muscarinic receptors in rat brain and comparative analysis of minimum energy conformations.

    Collins D et al (1993) Neurochem Int 22(3) : 237-47.
    PubMedID: 8443567
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