5-aza-2'-deoxycytidine (Decitabine)

(HB1356)

Product overview

  • Name
    5-aza-2'-deoxycytidine (Decitabine)
  • Short description
    DNA methyltransferase inhibitor
  • Biological description
    DNA methyltransferase inhibitor. Prevents DNA methylation after incorporation into DNA. Enhances histone deacetylase (HDAC) inhibitor-induced apoptosis. Shows actions against atherosclerosis and cancer.
  • Alternative names
    5-Aza-CdR, 5-Aza-dC, 5-Deoxy-2'-azacytidine; Decitabine; ZdCyd; DAC
  • Biological action
    Inhibitor
  • Purity
    >99%
  • Our products in action

Properties

  • Chemical name
    4-Amino-1-(2-deoxy-β-D-erythro-pento furanosyl)-1,3,5-triazin-2(1H)-one
  • Molecular Weight
    228.21
  • Molecular Formula
    C8H12N4O4
  • CAS Number
    2353-33-5

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    soluble in water (50mM) or DMSO (50mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for 5-aza-2'-deoxycytidine (Decitabine)

  • 5-Azacytidine and 5-aza-2'-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy.

    Christman JK (2002) Oncogene 21(35) : 5483-95.
    PubMedID: 12154409
  • Inhibiting DNA Methylation by 5-Aza-2'-deoxycytidine ameliorates atherosclerosis through suppressing macrophage inflammation.

    Cao Q et al (2014) Endocrinology 155(12) : 4925-38.
    PubMedID: 25251587
  • DNA methyltransferase inhibition enhances apoptosis induced by histone deacetylase inhibitors.

    Zhu WG et al (2001) Cancer Res 61(4) : 1327-33.
    PubMedID: 11245429
  • Resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in neuroblastoma cells correlates with a loss of caspase-8 expression.

    Eggert A et al (2001) Cancer Res 61(4) : 1314-9.
    PubMedID: 11245427

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