5-Azacytidine

(HB1374)

Product overview

  • Name
    5-Azacytidine
  • Short description
    DNA methyltransferase inhibitor. Improves stem cell reprogramming efficiency.
  • Biological description
    DNA methyltransferase inhibitor. Causes hypomethylation. Inhibits Wnt-β-catenin signaling pathway and improves stem cell reprogramming efficiency. Shows anti-viral, anti-proliferative and anti-cancer actions.
  • Alternative names
    5-AzadCyD; NSC 102816; azaCyd; 5-AZC
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    4-Amino-1-β-D-ribofuranosyl-1,3,5-tr iazin-2(1H)-one
  • Molecular Weight
    244.2
  • Chemical structure
    5-Azacytidine  [320-67-2]
  • Molecular Formula
    C8H12N4O5
  • CAS Number
    320-67-2

Storing and Using Your Product

  • Storage instructions
    room temperature
  • Solubility overview
    soluble in water (50mM) or DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for 5-Azacytidine

  • 5-Azacytidine suppresses the proliferation of pancreatic cancer cells by inhibiting the Wnt/β-catenin signaling pathway.

    Zhang H et al (2014) Genet Mol Res 13(3) : 5064-72.
    PubMedID: 25061731
  • 5-azacytidine reduces methylation, promotes differentiation and induces tumor regression in a patient-derived IDH1 mutant glioma xenograft.

    Borodovsky A et al (2013) Oncotarget 4(10) : 1737-47.
    PubMedID: 24077805
  • 5-Azacytidine can induce lethal mutagenesis in human immunodeficiency virus type 1.

    Dapp MJ et al (2009) J Virol 83(22) : 11950-8.
    PubMedID: 19726509