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Biological Data
Biological description | DNA methyltransferase inhibitor. Causes hypomethylation. Inhibits Wnt-β-catenin signaling pathway and improves stem cell reprogramming efficiency and induces differentiation of Mesenchymal Stem cells (MSCs) into cardiomyocytes. Shows anti-viral, anti-proliferative and anti-cancer actions. |
Solubility & Handling
Storage instructions | Room temperature |
Solubility overview | Soluble in water (50mM) or DMSO (100mM) |
Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
Chemical name | 4-Amino-1-β-D-ribofuranosyl-1,3,5-tr iazin-2(1H)-one |
Chemical structure | |
Molecular Formula | C8H12N4O5 |
SMILES | O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N2C(N=C(N)N=C2)=O |
InChiKey | NMUSYJAQQFHJEW-KVTDHHQDSA-N |
References for 5-Azacytidine
References are publications that support the biological activity of the product
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5-Azacytidine suppresses the proliferation of pancreatic cancer cells by inhibiting the Wnt/β-catenin signaling pathway.
Zhang H et al (2014) Genet Mol Res 13(3) : 5064-72. -
5-azacytidine reduces methylation, promotes differentiation and induces tumor regression in a patient-derived IDH1 mutant glioma xenograft.
Borodovsky A et al (2013) Oncotarget 4(10) : 1737-47. -
5-Azacytidine can induce lethal mutagenesis in human immunodeficiency virus type 1.
Dapp MJ et al (2009) J Virol 83(22) : 11950-8.
DNA methyltransferase inhibitor. Improves stem cell reprogramming efficiency and induces differentiation of MSCs into cardiomyocytes.