5'-Iodoresiniferatoxin

(HB1193)

Product overview

  • Name
    5'-Iodoresiniferatoxin
  • Short description
    Potent TRPV1 channel antagonist
  • Biological description
    Potent TRPV1 channel antagonist. Decreases UV-induced matrix metalloproteinase, pro-inflammatory cytokines and COX-2 expression. Blocks TRPV1 dependent neural hypersensitivity and thermal hyperalgesia.
  • Biological action
    Antagonist
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    6,7-Deepoxy-6,7-didehydro-5-deoxy-2 1-dephenyl-21-(phenylmethyl)-daphnetoxin,20-(4-hydroxy-5-iodo-3-methoxybenzeneacetate)
  • Molecular Weight
    754.6
  • Chemical structure
    5'-Iodoresiniferatoxin  [535974-91-5]
  • Molecular Formula
    C37H39IO9
  • CAS Number
    535974-91-5

Storing and Using Your Product

  • Storage instructions
    -20°C (desiccate)
  • Solubility overview
    soluble in DMSO or ethanol (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for 5'-Iodoresiniferatoxin

  • Inhibitory effects of TRPV1 blocker on UV-induced responses in the hairless mice.

    Lee YM et al (2011) Arch Dermatol Res 303(10) : 727-36.
    PubMedID: 21656169
  • Enhancement of spontaneous and heat-evoked activity in spinal nociceptive neurons by the endovanilloid/endocannabinoid N-arachidonoyldopamine (NADA).

    Huang SM et al (2006) J Neurophysiol 95(2) : 1207-12.
    PubMedID: 16267120
  • Differential regulation of peripheral IL-1β-induced mechanical allodynia and thermal hyperalgesia in rats.

    Kim MJ et al (2014) Pain 155(4) : 723-32.
    PubMedID: 24406203

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