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6-Hydroxydopamine (6-OHDA) hydrobromide

(HB1889)
Data

Product overview

  • Name
    6-Hydroxydopamine (6-OHDA) hydrobromide
  • Short description
    Neurotoxin, widely used to produce the 6-OHDA Parkinson’s disease model
  • Biological description

    6-hydroxydopamine hydrobromide (6-OHDA) is widely used to lesion the nigrostriatal dopaminergic system as a model of Parkinson’s disease (6-OHDA lesion model).


    6-OHDA is commonly unilaterally administered into the medial forebrain bundle (MFB), substantia nigra or striatum to induce a selective depletion of dopamine neurons to reproduce behavioural deficits seen in Parkinson’s disease. Varying degrees of neurodegeneration occur depending on site of administration.


    Unilateral administration of 6-OHDA into one hemisphere (hemiparkinsonian model) permits assessment of a quantifiable turning behaviour which can be correlated with the magnitude of the nigrostriatal lesions. Bilateral 6-OHDA lesion models may also be used.

  • Alternative names
    6-OHDA, Oxidopamine
  • Biological action
    Toxin
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    5-(2-Aminoethyl)-1,2,4-benzenetriol hydrobromide
  • Molecular Weight
    250.09
  • Chemical structure
    6-Hydroxydopamine hydrobromide [636-00-0]
  • Molecular Formula
    C8H11NO3 · HBr
  • CAS Number
    636-00-0
  • PubChem identifier
    176170
  • SMILES
    C1=C(C(=CC(=C1O)O)O)CCN.Br
  • InChi
    InChI=1S/C8H11NO3.BrH/c9-2-1-5-3-7(11)8(12)4-6(5)10;/h3-4,10-12H,1-2,9H2;1H
  • InChiKey
    MLACDGUOKDOLGC-UHFFFAOYSA-N
  • MDL number
    MFCD00012894
  • Appearance
    Off-white solid

Storing and Using Your Product

  • Storage instructions
    RT (desiccate)
  • Solubility overview
    Soluble in water (100 mM) and in DMSO (100 mM)
  • Handling
    This compound is air sensitive; exposure to air may affect compound performance. We therefore recommend storing the material in a sealed jar. Do not store the material in solution; make up solutions and use immediately.
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

References for 6-Hydroxydopamine (6-OHDA) hydrobromide

  • A guide to neurotoxic animal models of Parkinson's disease.

    Tieu K (2011) Cold Spring Harb Perspect Med 1(1) : a009316
  • Unilateral Lesion of Dopamine Neurons Induces Grooming Asymmetry in the Mouse.

    Pelosi et al (2015) PLoS One 10(9) : e137185
    PubMedID: 26397369
  • Limitations of animal models of Parkinson's disease.

    Potashkin et al (2010) Parkinsons Dis 2011:658083 : 20
    PubMedID: 21209719
  • Behavioral characterization of a unilateral 6-OHDA-lesion model of Parkinson's disease in mice.

    Iancu et al (2005) Behav Brain Res. 162(1) : 1-10
    PubMedID: 15922062
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