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6-Thioguanine

(HB1379)
Data

Product overview

  • Name
    6-Thioguanine
  • Short description
    Competitive hypoxanthine-guanine phosphoribosyltransferase substrate
  • Biological description
    Competitive hypoxanthine-guanine phosphoribosyltransferase substrate. An antimetabolite guanine analogue that inhibits DNA methylation. Shows anti-cancer and anti-angiogenic actions.
  • Alternative names
    6-TG; Tioguanine
  • Biological action
    Substrate
  • Purity
    >99%
  • Citations

Properties

  • Chemical name
    2-Amino-6-mercaptopurine
  • Molecular Weight
    167.19
  • Chemical structure
    6-Thioguanine  [154-42-7]
  • Molecular Formula
    C5H5N5S
  • CAS Number
    154-42-7

Storing and Using Your Product

  • Storage instructions
    room temperature
  • Solubility overview
    soluble in DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for 6-Thioguanine

  • Thioguanine, mercaptopurine: their analogs and nucleosides as antimetabolites.

    Elgemeie GH (2003) Curr Pharm Des 9(31) : 2627-42.
    PubMedID: 14529546
  • 6-Thioguanine perturbs cytosine methylation at the CpG dinucleotide site by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo.

    Wang H et al (2009) Biochemistry 48(10) : 2290-9.
    PubMedID: 19236003
  • Anti-angiogenic activity of the purine analog 6-thioguanine.

    Presta M et al (2002) Leukemia 16(8) : 1490-9.
    PubMedID: 12145690
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