6'-Iodoresiniferatoxin

(HB1180)

Product overview

  • Name
    6'-Iodoresiniferatoxin
  • Short description
    TRPV1 receptor partial agonist
  • Biological description
    TRPV1 receptor partial agonist (Ki = 0.71 nM for hVR1). Full agonist at rat VR1.
  • Biological action
    Agonist
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    [(2S,3aR,3bS,6aR,9aR,9bR,10R,11aR)-3a,3b,6,6a,9a,10,11,11a-octahydro-6a-hydroxy-8,10- dimethyl-11a-(1-methylethenyl)-7-oxo-2-(phenylmeth yl)-7H-2,9b-epoxyazuleno[5,4-e]-1,3-benzodioxol-5-yl]-4-hydroxy-2-iodo-5-methoxy-benzeneacetic acid methyl ester
  • Molecular Weight
    754.6
  • Molecular Formula
    C37H39IO9
  • CAS Number
    335151-55-8

Storing and Using Your Product

  • Storage instructions
    -20°C (desiccate)
  • Solubility overview
    soluble in ethanol or DMSO
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for 6'-Iodoresiniferatoxin

  • Synthesis and in vitro evaluation of a novel iodinated resiniferatoxin derivative that is an agonist at the human vanilloid VR1 receptor.

    McDonnell ME et al (2002) Bioorg Med Chem Lett 12(8) : 1189-92.
    PubMedID: 11934585
  • The taming of capsaicin. Reversal of the vanilloid activity of N-acylvanillamines by aromatic iodination.

    Appendino G et al (2005) J Med Chem 48(14) : 4663-9.
    PubMedID: 16000002
  • Low Frequency Electroacupuncture Alleviated Spinal Nerve Ligation Induced Mechanical Allodynia by Inhibiting TRPV1 Upregulation in Ipsilateral Undamaged Dorsal Root Ganglia in Rats.

    Jiang YL et al (2013) Evid Based Complement Alternat Med 2013 : 170910
    PubMedID: 23935654

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