Pack	Price	Qty
10mg	$264
50mg	$1,053

MMPX

(HB0092)

Product overview

Name
MMPX
Short description
Selective calmodulin-dependent PDE-1 inhibitor
Biological description
Selective calmodulin-dependent phosphodiesterase 1 (PDE-1) inhibitor. Increases Ca²⁺-activated K⁺ (BK) channel activity in the urinary bladder and shows smooth muscle relaxing actions. Also shows vasodilator actions.
Alternative names
8-Methoxymethyl-IBMX
Biological action
Inhibitor
Purity
>98%
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Effects of selective inhibitors on cyclic nucleotide phosphodiesterases of rabbit aorta.
Ahn HS et al (1989) Biochem Pharmacol 38(19) : 3331-9.
PubMedID: 2554921
Selective inhibition of phosphodiesterase 1 relaxes urinary bladder smooth muscle: role for ryanodine receptor-mediated BK channel activation.
Xin W et al (2012) Am J Physiol Cell Physiol 303(10) : C1079-89.
PubMedID: 22992675
In vivo effects of phosphodiesterase inhibition on basal cyclic guanosine monophosphate levels in the prefrontal cortex, hippocampus and cerebellum of freely moving rats.
Marte A et al (2008) J Neurosci Res 86(15) : 3338-47.
PubMedID: 18655195
Lung vasodilatory response to inhaled iloprost in experimental pulmonary hypertension: amplification by different type phosphodiesterase inhibitors.
Schermuly RT et al (2005) Respir Res 6 : 76
PubMedID: 16033645