MMPX
(HB0092)- Data
- Support & Resources
Data
Product overview
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Name
MMPX
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Short description
Selective calmodulin-dependent PDE-1 inhibitor
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Biological description
Selective calmodulin-dependent phosphodiesterase 1 (PDE-1) inhibitor. Increases Ca2+-activated K+ (BK) channel activity in the urinary bladder and shows smooth muscle relaxing actions. Also shows vasodilator actions.
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Alternative names
8-Methoxymethyl-IBMX
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Biological action
Inhibitor
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Purity
>98%
- Citations
Properties
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Molecular Weight
266.3
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Chemical structure
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Molecular Formula
C12H18N4O3
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CAS Number
78033-08-6
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PubChem identifier
155806
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SMILES
CC(C)CN1C2=C(C(=O)N(C1=O)C)NC(=N2)COC
Storing and Using Your Product
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Storage instructions
room temperature
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Solubility overview
soluble in ethanol or DMOS (5mg/ml)
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Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for MMPX
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Effects of selective inhibitors on cyclic nucleotide phosphodiesterases of rabbit aorta.
Ahn HS et al (1989) Biochem Pharmacol 38(19) : 3331-9.PubMedID: 2554921 -
Selective inhibition of phosphodiesterase 1 relaxes urinary bladder smooth muscle: role for ryanodine receptor-mediated BK channel activation.
Xin W et al (2012) Am J Physiol Cell Physiol 303(10) : C1079-89.PubMedID: 22992675 -
In vivo effects of phosphodiesterase inhibition on basal cyclic guanosine monophosphate levels in the prefrontal cortex, hippocampus and cerebellum of freely moving rats.
Marte A et al (2008) J Neurosci Res 86(15) : 3338-47.PubMedID: 18655195 -
Lung vasodilatory response to inhaled iloprost in experimental pulmonary hypertension: amplification by different type phosphodiesterase inhibitors.
Schermuly RT et al (2005) Respir Res 6 : 76PubMedID: 16033645
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