Product overview

  • Name
    A 484954
  • Short description
    Potent, selective eEF-2K / CaMKIII inhibitor
  • Biological description
    Potent and selective eukaryotic elongation factor-2 kinase (eEF-2K / CAMKIII) inhibitor (IC50 = 420 nM). Reduces eEF-2 phosphorylation.
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    7-Amino-1-cyclopropyl-3-ethyl-1,2,3,4-tetrahydro-2,4-dioxopyrido[2,3-d]pyrimidine-6-carboxamide
  • Molecular Weight
    289.29
  • Chemical structure
    A 484954  [142557-61-7]
  • Molecular Formula
    C13H15N5O3
  • CAS Number
    142557-61-7

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    soluble in DMSO (10mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for A 484954

  • 1-Benzyl-3-cetyl-2-methylimidazolium iodide (NH125) induces phosphorylation of eukaryotic elongation factor-2 (eEF2): a cautionary note on the anticancer mechanism of an eEF2 kinase inhibitor.

    Chen Z et al (2011) J Biol Chem 286(51) : 43951-8.
    PubMedID: 22020937
  • Synthesis and biological evaluation of pyrido[2,3-d]pyrimidine-2,4-dione derivatives as eEF-2K inhibitors.

    Edupuganti R et al (2014) Bioorg Med Chem 22(17) : 4910-6.
    PubMedID: 25047940
  • Eukaryotic elongation factor 2 kinase controls proliferation and migration of vascular smooth muscle cells.

    Usui T et al (2014) Acta Physiol (Oxf) :
    PubMedID: 25069823

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