A 769662

(HB1351)

Product overview

  • Name
    A 769662
  • Short description
    Potent, reversible AMPK activator. Inhibits MSC proliferation.
  • Biological description
    Potent reversible AMP-activated protein kinase (AMPK) activator (EC50 = 0.8 µM). Activates AMPK allosterically and inhibits AMPK dephosphorylation. Also Na+ - K+- ATPase inhibitor (IC50 values are 57 and 220 µM for rat and human respectively). Stimulates glucose uptake and decreases fatty acid synthase levels. Additionally shown to inhibit MSC proliferation.
  • Biological action
    Activator
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    6,7-Dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile
  • Molecular Weight
    360.39
  • Chemical structure
    A 769662  [844499-71-4]
  • Molecular Formula
    C20H12N2O3S
  • CAS Number
    844499-71-4
  • PubChem identifier
    54708532
  • SMILES
    C1=CC=C(C(=C1)C2=CC=C(C=C2)C3=CSC4=C3C(=C(C(=O)N4)C#N)O)O
  • InChi
    InChI=1S/C20H12N2O3S/c21-9-14-18(24)17-15(10-26-20(17)22-19(14)25)12-7-5-11(6-8-12)13-3-1-2-4-16(13)23/h1-8,10,23H,(H2,22,24,25)
  • InChiKey
    CTESJDQKVOEUOY-UHFFFAOYSA-N

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    Soluble in DMSO (100 mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for A 769662

  • Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome.

    Cool B et al (2006) Cell Metab 3(6) : 403-16.
    PubMedID: 16753576
  • AMP-activated protein kinase activator A-769662 is an inhibitor of the Na(+)-K(+)-ATPase.

    Benziane B et al (2009) Am J Physiol Cell Physiol 297(6) : C1554-66.
    PubMedID: 19828836
  • Beyond AICA riboside: in search of new specific AMP-activated protein kinase activators.

    Guigas B et al (2009) IUBMB Life 61(1) : 18-26.
    PubMedID: 18798311