Product overview

  • Name
    A 803467
  • Short description
    Potent, selective Nav1.8 channel inhibitor
  • Biological description
    Potent and selective voltage-dependent Nav1.8 channel inhibitor (IC50 = 8 nM). Shows >100-fold selectivity over Nav1.3, Nav1.7, Nav1.5 and Nav1.2 channels. Blocks tetrodotoxin resistant currents (IC50 = 140 nM). Shows antinociceptive actions.
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)-2-furancarboxamide
  • Molecular Weight
    357.79
  • Chemical structure
    A 803467  [944261-79-4]
  • Molecular Formula
    C19H16ClNO4
  • CAS Number
    944261-79-4

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    soluble in DMSO (100mM) or ethanol (25mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for A 803467

  • A selective Nav1.8 sodium channel blocker, A-803467 [5-(4-chlorophenyl-N-(3,5-dimethoxyphenyl)furan-2-carboxamide], attenuates spinal neuronal activity in neuropathic rats.

    McGaraughty S et al (2008) J Pharmacol Exp Ther 324(3) : 1204-11.
    PubMedID: 18089840
  • A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat.

    Jarvis MF et al (2007) Proc Natl Acad Sci U S A 104(20) : 8520-5.
    PubMedID: 17483457
  • Tetrodotoxin-resistant sodium channels in sensory neurons generate slow resurgent currents that are enhanced by inflammatory mediators.

    Tan ZY et al (2014) J Neurosci 34(21) : 7190-7.
    PubMedID: 24849353

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