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Data

Product overview

  • Name
    A 967079
  • Short description
    Potent, selective TRPA1 channel blocker
  • Biological description
    Potent and selective TRPA1 channel blocker (IC50 values are 67 and 289 nM for human TRPA1 and rat TRPA1 channels respectively). Exhibits greater than 1000-fold selectivity for TRPA1 over other TRP channels. Exhibits analgesic actions. Does not alter body temperature unlike other TRPV1 channel blockers.
  • Biological action
    Blocker
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    (1E,3E)-1-(4-Fluorophenyl)-2-methyl-1-pentene-3-one oxime
  • Molecular Weight
    207.24
  • Chemical structure
    A 967079  [1170613-55-4]
  • Molecular Formula
    C12H14FNO
  • CAS Number
    1170613-55-4
  • PubChem identifier
    42641861
  • SMILES
    CC/C(=N\O)/C(=C/C1=CC=C(C=C1)F)/C
  • InChi
    InChI=1S/C12H14FNO/c1-3-12(14-15)9(2)8-10-4-6-11(13)7-5-10/h4-8,15H,3H2,1-2H3/b9-8+,14-12+
  • InChiKey
    HKROEBDHHKMNBZ-CHBKHGQFSA-N
  • MDL number
    MFCD20488058

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    Soluble in DMSO (100mM), and in ethanol (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for A 967079

  • Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation.

    Chen J et al (2011) Pain 152(5) : 1165-72.
    PubMedID: 21402443
  • TRPA1 modulation of spontaneous and mechanically evoked firing of spinal neurons in uninjured, osteoarthritic, and inflamed rats.

    McGaraughty S et al (2010) Mol Pain 6 : 14
    PubMedID: 20205719
  • TRPV1 and TRPA1 antagonists prevent the transition of acute to chronic inflammation and pain in chronic pancreatitis.

    Schwartz ES et al (2013) J Neurosci 33(13) : 5603-11.
    PubMedID: 23536075
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