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Product overview

  • Name
    A 967079
  • Short description
    Potent, selective TRPA1 channel blocker
  • Biological description
    Potent and selective TRPA1 channel blocker (IC50 values are 67 and 289 nM for human TRPA1 and rat TRPA1 channels respectively). Exhibits greater than 1000-fold selectivity for TRPA1 over other TRP channels. Exhibits analgesic actions. Does not alter body temperature unlike other TRPV1 channel blockers.
  • Biological action
  • Purity
  • Citations


  • Chemical name
    (1E,3E)-1-(4-Fluorophenyl)-2-methyl-1-pentene-3-one oxime
  • Molecular Weight
  • Chemical structure
    A 967079  [1170613-55-4]
  • Molecular Formula
  • CAS Number

Storing and Using Your Product

  • Storage instructions
  • Solubility overview
    soluble in DMSO (100mM) or ethanol (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for A 967079

  • Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation.

    Chen J et al (2011) Pain 152(5) : 1165-72.
    PubMedID: 21402443
  • TRPA1 modulation of spontaneous and mechanically evoked firing of spinal neurons in uninjured, osteoarthritic, and inflamed rats.

    McGaraughty S et al (2010) Mol Pain 6 : 14
    PubMedID: 20205719
  • TRPV1 and TRPA1 antagonists prevent the transition of acute to chronic inflammation and pain in chronic pancreatitis.

    Schwartz ES et al (2013) J Neurosci 33(13) : 5603-11.
    PubMedID: 23536075
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