In my cart

You have no items in your shopping cart.

Calcium Ionophore A23187


Product overview

  • Name
    Calcium Ionophore A23187
  • Short description
    Non-selective calcium ionophore
  • Biological description

    Non-selective calcium ionophore which facilitates transport of Ca2+ across the plasma membrane.

    Increases intracellular Ca2+ concentration to induce Ca2+-dependent cell death. Also increases Zn2+ and Fe2+ permeability across the cell membrane.

    Induces ROS and oxidative platelet particle formation.

    Also activates IKK2 and NF-κB in mast cells, induces cytokine production and degranulation.

    Additionally shown to induce apoptosis and autophagy.

  • Alternative names
  • Biological action
  • Purity
  • Citations


  • Chemical name
    5-(Methylamino)-2-[[2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyr rol-2-yl)-ethyl]-1,7-dioxaspiro[5.5]undec-2-yl]methyl]-4-benzoxazolecarboxylic acid
  • Molecular Weight
  • Chemical structure
    A23187  [52665-69-7]
  • Molecular Formula
  • CAS Number
  • PubChem identifier
  • InChi
  • InChiKey
  • MDL number

Storing and Using Your Product

  • Storage instructions
    +4°C (desiccate)
  • Solubility overview
    Soluble in DMSO (50mM) and in ethanol (10mM, gentle warming)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Calcium Ionophore A23187

  • Zn(2+), derived from cell preparation, partly attenuates Ca(2+)-dependent cell death induced by A23187, calcium ionophore, in rat thymocytes.

    Sakanashi Y et al (2009) Toxicol In Vitro 23(2) : 338-45.
    PubMedID: 19124067
  • Platelet particle formation by anti GPIIIa49-66 Ab, Ca2+ ionophore A23187, and phorbol myristate acetate is induced by reactive oxygen species and inhibited by dexamethasone blockade of platelet phospholipase A2, 12-lipoxygenase, and NADPH oxidase.

    Nardi MA et al (2007) Blood 110(6) : 1989-96.
    PubMedID: 17545506
  • Role of calcium ionophore A23187-induced activation of IkappaB kinase 2 in mast cells.

    Hosokawa J et al (2013) Int Arch Allergy Immunol 161 Suppl 2 : 37-43.
    PubMedID: 23711852
Our products in action
The following papers have cited the use of Calcium Ionophore A23187 (HB1000) from Hello Bio. If you have published a paper using this product, and it is not shown here, then please tell us! We will send you a free gift as a thank you!
  • Molecular Mechanisms of Synaptic Vesicle Priming by Munc13 and Munc18.

    Lai et al(2017) Neuron. 95(3) : 591-607
    PubMedID: 28772123
Support & Resources

Reviews & Product Guides