Calcium Ionophore A23187

(HB1000)

Product overview

  • Name
    Calcium Ionophore A23187
  • Short description
    Non-selective calcium ionophore
  • Biological description

    Non-selective calcium ionophore which facilitates transport of Ca2+ across the plasma membrane.

    Increases intracellular Ca2+ concentration to induce Ca2+-dependent cell death. Also increases Zn2+ and Fe2+ permeability across the cell membrane.

    Induces ROS and oxidative platelet particle formation.

    Also activates IKK2 and NF-κB in mast cells, induces cytokine production and degranulation.

    Additionally shown to induce apoptosis and autophagy.

  • Alternative names
    Calcimycin
  • Biological action
    Ionophore
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    5-(Methylamino)-2-[[2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyr rol-2-yl)-ethyl]-1,7-dioxaspiro[5.5]undec-2-yl]methyl]-4-benzoxazolecarboxylic acid
  • Molecular Weight
    523.63
  • Chemical structure
    A23187  [52665-69-7]
  • Molecular Formula
    C29H37N3O6
  • CAS Number
    52665-69-7
  • PubChem identifier
    40486
  • SMILES
    C[C@H]1CCC2([C@@H](C[C@H]([C@H](O2)C(C)C(=O)C3=CC=CN3)C)C)O[C@H]1CC4=NC5=C(O4)C=CC(=C5C(=O)O)NC
  • InChi
    InChI=1S/C29H37N3O6/c1-15-10-11-29(17(3)13-16(2)27(38-29)18(4)26(33)20-7-6-12-31-20)37-22(15)14-23-32-25-21(36-23)9-8-19(30-5)24(25)28(34)35/h6-9,12,15-18,22,27,30-31H,10-11,13-14H2,1-5H3,(H,34,35)/t15-,16+,17+,18?,22-,27-,29?/m0/s1
  • InChiKey
    HIYAVKIYRIFSCZ-CVXKHCKVSA-N
  • MDL number
    MFCD00151202

Storing and Using Your Product

  • Storage instructions
    +4°C (desiccate)
  • Solubility overview
    Soluble in DMSO (50mM) and in ethanol (10mM, gentle warming)

References for Calcium Ionophore A23187

  • Zn(2+), derived from cell preparation, partly attenuates Ca(2+)-dependent cell death induced by A23187, calcium ionophore, in rat thymocytes.

    Sakanashi Y et al (2009) Toxicol In Vitro 23(2) : 338-45.
    PubMedID: 19124067
  • Platelet particle formation by anti GPIIIa49-66 Ab, Ca2+ ionophore A23187, and phorbol myristate acetate is induced by reactive oxygen species and inhibited by dexamethasone blockade of platelet phospholipase A2, 12-lipoxygenase, and NADPH oxidase.

    Nardi MA et al (2007) Blood 110(6) : 1989-96.
    PubMedID: 17545506
  • Role of calcium ionophore A23187-induced activation of IkappaB kinase 2 in mast cells.

    Hosokawa J et al (2013) Int Arch Allergy Immunol 161 Suppl 2 : 37-43.
    PubMedID: 23711852

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