A-7 hydrochloride

(HB0097)

Product overview

  • Name
    A-7 hydrochloride
  • Short description
    Potent, cell-permeable calmodulin (CaM) antagonist
  • Biological description
    Potent calmodulin antagonist. Cell permeable. Napthalenesulfonamide W-7 analog. Inhibits calmodulin activated PDE activity (IC50 = 3 µM).
  • Biological action
    Antagonist
  • Our products in action

Properties

  • Chemical name
    N-(10-Aminodecyl)-5-chloro-1-naphthalenesulfonamide hydrochloride
  • Molecular Weight
    433.44
  • Chemical structure
    A-7 hydrochloride  [79127-24-5]
  • Molecular Formula
    C20H29ClN2O2S.HCl
  • CAS Number
    79127-24-5
  • PubChem identifier
    44119113
  • SMILES
    C1=CC2=C(C=CC=C2Cl)C(=C1)S(=O)(=O)NCCCCCCCCCCN.Cl

Storing and Using Your Product

  • Storage instructions
    room temperature
  • Solubility overview
    soluble in DMSO (50mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for A-7 hydrochloride

  • Naphthalenesulfonamides as calmodulin antagonists.

    Hidaka H et al (1983) Methods Enzymol 102 : 185-94.
    PubMedID: 6139736
  • Direct interaction of calmodulin antagonists with Ca2+/calmodulin-dependent cyclic nucleotide phosphodiesterase.

    Itoh H et al (1984) J Biochem 96(6) : 1721-6.
    PubMedID: 6099352

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