Product overview

Name A-7 hydrochloride
Description Potent, cell-permeable calmodulin (CaM) antagonist
Write Your Own Review
You're reviewing:A-7 hydrochloride
Rate this item:

Biological Data

Biological description Potent calmodulin antagonist. Cell permeable. Napthalenesulfonamide W-7 analog. Inhibits calmodulin activated PDE activity (IC50 = 3 µM).

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO (50mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

=
x
x
More Info

Dilution

x
=
x
More Info

Chemical Data

Chemical name N-(10-Aminodecyl)-5-chloro-1-naphthalenesulfonamide hydrochloride
Molecular Weight 433.44
Chemical structure A-7 hydrochloride  [79127-24-5] Chemical Structure
Molecular Formula C20H29ClN2O2S.HCl
CAS Number 79127-24-5
PubChem identifier 44119113
SMILES C1=CC2=C(C=CC=C2Cl)C(=C1)S(=O)(=O)NCCCCCCCCCCN.Cl
InChiKey XDJCAQBTSCRBHS-UHFFFAOYSA-N

References for A-7 hydrochloride

References are publications that support the biological activity of the product
  • Direct interaction of calmodulin antagonists with Ca2+/calmodulin-dependent cyclic nucleotide phosphodiesterase.

    Itoh H et al (1984) J Biochem 96(6) : 1721-6.
  • Naphthalenesulfonamides as calmodulin antagonists.

    Hidaka H et al (1983) Methods Enzymol 102 : 185-94.

2 Item(s)