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Biological Data

Biological description Competitive NMDA receptor partial agonist (Ki = 0.83 mM). Binds at glycine site. Shows 65-fold higher affinity for GluN3 compared to GluN1 subunit.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in water (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Chemical Data

Chemical name 1-Aminocyclobutane-1-carboxylic acid
Molecular Weight 115.13
Chemical structure ACBC  [22264-50-2] Chemical Structure
Molecular Formula C5H9NO2
CAS Number 22264-50-2
PubChem identifier 89643
SMILES NC1(CCC1)C(O)=O
InChiKey FVTVMQPGKVHSEY-UHFFFAOYSA-N

References for ACBC

References are publications that support the biological activity of the product
  • Pharmacology of NMDA Receptors

    Monaghan DT et al (2009) 0 :
  • Mechanism of partial agonist action at the NR1 subunit of NMDA receptors.

    Inanobe A et al (2005) Neuron 47(1) : 71-84.
  • 1-Aminocyclobutane-1-carboxylate (ACBC): a specific antagonist of the N-methyl-D-aspartate receptor coupled glycine receptor.

    Hood WF et al (1989) Eur J Pharmacol 161(2-3) : 281-2.

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