In my cart

You have no items in your shopping cart.


Product overview

  • Name
  • Short description
    Roscovitine-related purine with no activity on CDKs. Roscovitine control. Increases Aβ42 production.
  • Biological description
    Roscovitine-related purine with no activity on CDKs (used as control for roscovitine). Selectively and potently increases production of extracellular Abeta42 and decreases production of extracellular Abeta38 in cultured cells. Extracellular Abeta40 levels remain stable. Intracellular levels of these amyloids appear to remain stable. Alzheimer's Disease (AD) accelerator that interacts with VDAC1, prohibitin and mitofilin, possibly interfering with subcellular compartmentalization and lipid rafts properties, shifting gamma-secretase activity toward Abeta42 generation. Induces a reversible mitochondrial phenotype reminiscent of the one observed in AD brains. Tool to detect inhibitors of Aftin-induced actions (potential anti-AD compounds). Binds pyridoxal kinase.
  • Purity
  • Citations


  • Molecular Weight
  • Chemical structure
    Aftin-4 [866893-90-5]
  • CAS Number
  • InChiKey
  • Appearance
    White to off-white solid

Storing and Using Your Product

  • Storage instructions
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Support & Resources

Reviews & Product Guides